Non-termination of sickness behavior as precipitating factor for mental disorders

Show simple item record Viljoen, Margaretha Panzer, Annie 2007-06-18T11:28:54Z 2007-06-18T11:28:54Z 2005
dc.description.abstract Sickness behavior can be defined as a combination of coordinated behavioral and physiological changes that develop in response to any condition that elicits pro-inflammatory activity. It is an adaptational homeostasis initiated by the influence of pro-inflammatory cytokines on central nervous system neurohormonal functioning. This paper introduces the concept of non-termination of sickness behavior as a potential threat to mental health. In view of the similarities between the behavioral symptoms, the neuroendocrine and the cytokine profiles of sickness behavior and that of a number of mental disorders it is hypothesized that the inappropriate continuation of sickness behavior, (i.e., non-termination), after recovery from the initial disease, could form the basis for mental disturbances. This would be particularly relevant in individuals with alterations in stress vulnerability (altered activation threshold and impaired negative feedback), which may occur due to the combination of genetic disposition and priming by early life experiences. en
dc.format.extent 374525 bytes
dc.format.mimetype application/pdf
dc.identifier.citation Viljoen, M & Panzer, A 2005, ‘Non-termination of sickness behavior as precipitating factor for mental disorders’, Medical Hypotheses, vol. 64, no. 2, pp. 316-329. [ /science/journal/03069877] en
dc.identifier.issn 0306-9877
dc.identifier.other 10.1016/j.mehy.2004.08.032
dc.language.iso en en
dc.publisher Elsevier en
dc.rights Elsevier en
dc.subject Sickness behavior en
dc.subject Mental disorders en
dc.subject Central nervous system en
dc.subject.lcsh Sick--Psychology
dc.subject.lcsh Diseases--Relapse
dc.subject.lcsh Mental illness
dc.subject.lcsh Genetics
dc.title Non-termination of sickness behavior as precipitating factor for mental disorders en
dc.type Postprint Article en

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