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Browsing Research Articles (Chemical Pathology) by Issue Date

Browsing Research Articles (Chemical Pathology) by Issue Date

Now showing items 21-40 of 68

High molecular weight (HMW) : total adiponectin ratio is low in HIV-infected women receiving protease inhibitors

Omar, Fierdoz; Dave, Joel A.; King, Judy A.; Levitt, Naomi S.; Pillay, Tahir S. (BioMed Central, 2014)

BACKGROUND : At the time of the study, the HIV-treatment policy in South Africa included highly active antiretroviral therapy (HAART) regimens 1 (nucleotide reverse transcriptase inhibitors (NRTIs) only), and 2 (protease ...
Why are we still measuring red cell folate instead of just serum folate?

Pillay, Tahir S.; Oosthuizen, Nicholette M. (BMJ Publishing Group, 2014-04)

No abstract available.
Towards developing guidelines and systems of care to facilitate early reperfusion for ST-elevation myocardial infarction in Africa

Delport, Rhena (Clinics Cardive, 2014-11)

No abstract available.
Referral pathways for reperfusion of STEMI - developing strategies for appropriate intervention : the SA heart STEMI early intervention project

Snyders, Adriaan; Delport, Rhena (South African Heart Association, 2015)

The SA Heart Association seeks to to improve the early management of ST-segment elevation myocardial infarction in South Africa. This pilot study was undertaken to establish the current time intervals present in the ...
Exploration of the structural requirements of HIV-protease inhibitors using pharmacophore, virtual screening and molecular docking approaches for lead identification

Islam, Md Ataul; Pillay, Tahir S. (Elsevier, 2015-03)

Please abstract in the article.
Comparison of equations for the calculation of LDL-cholesterol in hospitalized patients

Martins, J.; Olorunju, Steve A.S.; Murray, L.M.; Pillay, Tahir S. (Elsevier, 2015-04)

BACKGROUND : The Friedewald equation is widely used to calculate LDL-C for cardiovascular risk prediction but is less accurate with comorbidities and extreme lipid values. Several novel formulae have been reported ...
Lack of association of rs3798220 with small apolipoprotein(a) isoforms and high lipoprotein(a) levels in East and Southeast Asians

Khalifa, Mahmoud; Noureen, Asma; Ertelthalner, Kathrin; Bandegi, Ahmad Reza; Delport, Rhena; Firdaus, Wance J.J.; Geethanjali, Finney S.; Luthra, Kalpana; Makemaharn, Orawan; Pang, Richard W.C.; Salem, Abdel-Halim; Sasaki, Jun; Schiefenhoevel, Wulf; Lingenhel, Arno; Kronenberg, Florian; Utermann, Gerd; Schmidt, Konrad (Elsevier, 2015-10)

OBJECTIVE : The variant allele of rs3798220 in the apolipoprotein(a) gene (LPA) is used to assess the risk for coronary artery disease (CAD) in Europeans, where it is associated with short alleles of the Kringle IV-2 (KIV-2) ...
Structural requirements for potential HIV-integrase inhibitors identified using pharmacophore-based virtual screening and molecular dynamics studies

Islam, Md Ataul; Pillay, Tahir S. (Royal Society of Chemistry, 2016)

Acquired immunodeficiency syndrome (AIDS) is a life-threatening disease which is a collection of symptoms and infections caused by a retrovirus, human immunodeficiency virus (HIV). There is currently no curative treatment ...
Identification of structural requirements of estrogen receptor modulators using pharmacoinformatics techniques for application to estrogen therapy

Islam, Md Ataul; Patel, Darshakkumar Ashokbhai; Rathod, Savansinh Ghanshyamsinh; Chunarkar, Preeti; Pillay, Tahir S. (Springer, 2016-03)

An attempt was made in the present study to explore the structural requirements of known estrogen receptor (ER) modulators for biological activity using pharmacoinformatics approaches to elucidate critical functionalities ...
Simplified molecular input line entry system-based descriptors in QSAR modeling for HIV-protease inhibitors

Islam, Md Ataul; Pillay, Tahir S. (Elsevier, 2016-04)

Simplified molecular input line entry system (SMILES) descriptor based quantitative structure–activity relationship (QSAR) study was performed on a set of HIV-protease inhibitors to explore the structural functionalities ...
Propensity of people of African descent towards hypertension-associated cardiovascular pathologies

Delport, Rhena (Nature Publishing Group, 2016-06)

No abstract available.
Case report : a toddler with anasarca caused by congenital nephrotic syndrome

Satekge, Tumelo M.; Kiabilua, Olivia; Van Biljon, Gertruida; Pillay, Komala; Pillay, Tahir S. (International Federation of Clinical Chemistry and Laboratory Medicine, 2017)

Congenital nephrotic syndrome is a rare inherited disorder arising from defects in the proteins of the cells in the glomerular basement membrane and develops either in utero or at birth. The clinical presentation is ...
Preliminary data on microRNA expression profiles in a group of South African patients diagnosed with chronic myeloid leukaemia

Prinsloo, Andrea; Pool, Andrea; Van Niekerk, Chantal (Spandidos Publications, 2017)

Micro‑ribonucleic acids (miRNAs) are small functional non‑coding RNAs that downregulate gene expression at the post‑transcriptional level. Abnormal expression of specific miRNAs has been recorded in chronic lymphocytic ...
Diabetes mellitus caused by mutations in human insulin : analysis of impaired receptor binding of insulins Wakayama, Los Angeles and Chicago using pharmacoinformatics

Islam, Md Ataul; Bhayye, Sagar; Adeniyi, Adebayo A.; Soliman, Mahmoud E.S.; Pillay, Tahir S. (Taylor and Francis, 2017-03)

Several naturally occuring mutations in the human insulin gene are associated with diabetes mellitus. The three known mutant molecules, Wakayama, Los Angeles and Chicago were evaluated using molecular docking and molecular ...
Cloning, expression and molecular modeling of the anthocyanidin reductase (FaANR) gene during strawberry fruit development

Mandave, P.C.; Kuvalekar, A.A.; Mantri, N.L.; Islam, Md Ataul; Ranjekar, P.K. (CIRAD, 2017-05)

INTRODUCTION - Proanthocyanidins (PAs) are a group of polyphenolic secondary metabolites synthesized in plants via flavonoid pathway. Strawberry (Fragaria × ananassa Duch.) is a rich source of flavonoids and proanthocyanins, ...
Identification of promising DNA GyrB inhibitors for Tuberculosis using pharmacophore-based virtual screening, molecular docking and molecular dynamics studies

Islam, Md Ataul; Pillay, Tahir S. (Wiley, 2017-08)

In the current study, we searched for potential DNA GyrB inhibitors using pharmacophorebased virtual screening followed by molecular docking and molecular dynamics simulation approaches. For this purpose, a set of 248 ...
Cinnamaldehyde, cinnamic acid, and cinnamyl alcohol, the bioactives of cinnamomum cassia exhibit HDAC8 inhibitory activity : an in vitro and in silico study

Patil, Mangesh; Choudhari, Amit S.; Pandita, Savita; Raina, Prerna; Kaul-Ghanekar, Ruchika (Medknow, 2017-10-11)

BACKGROUND : The altered expression of histone deacetylase family member 8 (HDAC8) has been found to be linked with various cancers, thereby making its selective inhibition a potential strategy in cancer therapy. ...
Chronic defensiveness and neuroendocrine dysfunction reflect a novel cardiac troponin T cut point : the SABPA study

Malan, Leoné; Hamer, Mark; Von Känel, Roland; Lambert, Gavin W.; Delport, Rhena; Steyn, Hendrik S.; Malan, Nicolaas T. (Elsevier, 2017-11)

BACKGROUND : Sympatho-adrenal responses are activated as an innate defense coping (DefS) mechanism during emotional stress. Whether these sympatho-adrenal responses drive cardiac troponin T (cTnT) increases are unknown. ...
The use of low-cost simulation in a resource-constrained teaching environment

Mwandri, M.; Walsh, M.; Frantz, J.; Delport, Rhena (Health and Medical Publishing Group, 2017-12)

BACKGROUND : To improve the management of chest trauma at the University of Botswana, Gaborone, Botswana, we incorporated simulation into a theorybased chest trauma module by developing procedural guides, checklists and ...
Appropriate strategies for South Africa for the management of acute myocardial infarction in patients presenting with ST-segment elevation

Delport, Rhena (Clinics Cardive, 2018-01)

Both patient and health-system delays contribute to delays in restoring myocardial perfusion. Patient-related delays constitute the time from onset of symptoms to the call for help, and onset of symptoms to first medical ...

Now showing items 21-40 of 68

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