• Variation in the measurement of anti-Mullerian hormone – what are the laboratory issues? 

  Punchoo, Rivak; Bhoora, Sachin (Frontiers Research Foundation, 2021-09-03)

  Anti-Müllerian Hormone (AMH) is a 140 kDa homodimeric glycoprotein consisting of two identical subunits linked by disulphide bonds and is synthesised by the testes and ovaries. Its clinical applications are prediction ...
• Structure-based screening of DNA GyraseB inhibitors for therapeutic applications in tuberculosis : a pharmacoinformatics study 

  Tambe, Pranjali Mahadeo; Bhowmick, Shovonlal; Chaudhary, Sushil Kumar; Khan, Mohammad Rizwan; Wabaidur, Saikh M.; Muddassir, Mohd.; Patil, Preeti Chunarkar; Islam, Md Ataul (Springer, 2020-12)

  Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB) and considered as serious public health concern worldwide which kills approximately five thousand people every day. Therefore, TB drug ...
• Application of single-domain antibodies ("nanobodies") to laboratory diagnosis 

  Pillay, Tahir S.; Muyldermans, Serge (Korean Society for Laboratory Medicine, 2021)

  Antibodies have proven to be central in the development of diagnostic methods over decades, moving from polyclonal antibodies to the milestone development of monoclonal antibodies. Although monoclonal antibodies play a ...
• Cholecalciferol inhibits cell growth and induces apoptosis in the CaSki cell line 

  Bhoora, Sachin; Pather, Yuvelia; Marais, Sumari; Punchoo, Rivak (MDPI, 2020-02)

  Vitamin D has displayed anti-cancer actions in numerous in vitro studies. Here, we investigated the anti-cancer actions of cholecalciferol, a vitamin D precursor, on a metastatic cervical cancer cell line, namely, CaSki. ...
• Humoral hypercalcaemia in an infant : a diagnostic dilemma 

  Chale-Matsau, Bettina (BMJ Publishing Group Group, 2021-06)

  Hypercalcaemia is seldom encountered in paediatric patients, and calcium levels are not routinely included in investigations. Associated symptoms such as nausea, vomiting, dehydration and abdominal pain are non-specific, ...
• Policing cancer : vitamin D arrests the cell cycle 

  Bhoora, Sachin; Punchoo, Rivak (MDPI, 2020-12)

  Vitamin D is a steroid hormone crucial for bone mineral metabolism. In addition, vitamin D has pleiotropic actions in the body, including anti-cancer actions. These anti-cancer properties observed within in vitro studies ...
• Multi-step molecular docking and dynamics simulation-based screening of large antiviral specific chemical libraries for identification of Nipah virus glycoprotein inhibitors 

  Kalbhor, Malti Sanjay; Bhowmick, Shovonlal; Alanazi, Amer M.; Patil, Pritee Chunarkar; Islam, Md Ataul (Elsevier, 2021-03)

  Nipah virus (NiV) infections are highly contagious and can cause severe febrile encephalitis. An outbreak of NiV infection has reported high mortality rates in Southeast Asian countries including Bangladesh, East Timor, ...
• Analysis of the role of nuclear factor-kappa B in insulin resistance caused by antiretroviral drugs 

  Mabugana, Matamela Charles (University of Pretoria, 2020)

  Human immunodeficiency virus still remains the leading cause of death globally including women of child-bearing age. The rate of AIDS-related death has significantly declined since the introduction of antiretroviral ...
• Potential anticancer actions of cholecalciferol on a cervical squamous carcinoma cell line 

  Bhoora, Sachin (University of Pretoria, 2020)

  Cervical cancer is the fourth most common female malignancy worldwide and is substantively higher in low-income and middle-income countries. In South Africa, cervical cancer is a leading cause of mortality amongst women. ...
• Gene of the month : the 2019-nCoV/ SARS-CoV- 2 novel coronavirus spike protein 

  Pillay, Tahir S. (BMJ Publishing Group, 2020-07)

  The year 2020 has seen a major and sustained outbreak of a novel betacoronavirus (severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2) infection that causes fever, severe respiratory illness and pneumonia, a ...
• Computational screening of promising beta-secretase 1 inhibitors through multi-step molecular docking and molecular dynamics simulations - pharmacoinformatics approach 

  Gupta, Shruti; Parihar, Devendra; Shah, Mokshada; Yadav, Shivali; Managori, Husain; Bhowmick, Shovonlal; Patil, Preeti Chunarkar; Alissa, Siham A.; Wabaidur, Saikh Mohammad; Islam, Md Ataul (Elsevier, 2020-04)

  Alzheimer’s disease (AD) is a neurodegenerative disorder generally developed with aging. AD slowly hammers the memory and cognitive abilities which eventually leads to abnormal behaviour, and ultimately left with disability ...
• β-secretase inhibitors for Alzheimer’s disease : identification using pharmacoinformatics 

  Islam, Md Ataul; Pillay, Tahir S. (Taylor and Francis, 2019)

  Please read abstract in the article.
• Pharmacoinformatics-based identification of chemically active molecules against Ebola virus 

  Islam, Md Ataul; Pillay, Tahir S. (Taylor and Francis, 2019)

  Ebola is a dangerous virus transmitted by animals and humans and to date there is no curable agent for such a deadly infectious disease. In this study, pharmacoinformatics-based methods were adopted to find effective novel ...
• Molecular dynamics and combined docking studies for the identification of Zaire ebola virus inhibitors 

  Sulaiman, Kazeem O.; Kolapo, Temitope U.; Onawole, Abdulmujeeb T.; Islam, Md Ataul; Adegokeg, Rukayat O.; Badmus, Suaibu O. (Taylor and Francis, 2019)

  Ebola virus (EBOV) is a lethal human pathogen with a risk of global spread of its zoonotic infections, and Ebolavirus Zaire specifically has the highest fatality rate amongst other species. There is a need for continuous ...
• Pharmacoinformatics-based identification of anti-bacterial catalase-peroxidase enzyme inhibitors 

  Jangam, Chaitanya Sadashiv; Bhowmick, Shovonlal; Chorge, Rekha Dhondiram; Bharatrao, Lomate Dhanraj; Patil, Pritee Chunarkar; Chikhale, Rupesh V.; AlFaris, Nora Abdullah; ALTamimi, Jozaa zaidan; Wabaidur, Saikh Mohammad; Islam, Md Ataul (Elsevier, 2019-12)

  Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb). In the present age, due to the rapid increase in antibiotic resistance worldwide, TB has become a major threat to human life. Regardless ...
• Discordant calcium and parathyroid hormone with presumed epileptic seizures 

  Chale-Matsau, Bettina; Van Niekerk, Chantal; Kemp, Tanja; Pillay, Tahir S. (American Association for Clinical Chemistry, 2018-03)

  A 33-year-old woman presented for the first time at the age of 9 years with recurrent seizures and was subsequently treated for epilepsy for 2 years. At 11 years of age, it was noted that the patient had hypocalcemia ...
• Propensity of people of African descent towards hypertension-associated cardiovascular pathologies 

  Delport, Rhena (Nature Publishing Group, 2016-06)

  No abstract available.
• Case report : a toddler with anasarca caused by congenital nephrotic syndrome 

  Satekge, Tumelo M.; Kiabilua, Olivia; Van Biljon, Gertruida; Pillay, Komala; Pillay, Tahir S. (International Federation of Clinical Chemistry and Laboratory Medicine, 2017)

  Congenital nephrotic syndrome is a rare inherited disorder arising from defects in the proteins of the cells in the glomerular basement membrane and develops either in utero or at birth. The clinical presentation is ...
• Appropriate strategies for South Africa for the management of acute myocardial infarction in patients presenting with ST-segment elevation 

  Delport, Rhena (Clinics Cardive, 2018-01)

  Both patient and health-system delays contribute to delays in restoring myocardial perfusion. Patient-related delays constitute the time from onset of symptoms to the call for help, and onset of symptoms to first medical ...
• The use of low-cost simulation in a resource-constrained teaching environment 

  Mwandri, M.; Walsh, M.; Frantz, J.; Delport, Rhena (Health and Medical Publishing Group, 2017-12)

  BACKGROUND : To improve the management of chest trauma at the University of Botswana, Gaborone, Botswana, we incorporated simulation into a theorybased chest trauma module by developing procedural guides, checklists and ...

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