Hsp70 induction and hsp70 gene polymorphisms as indicators of acclimatization under hyperthermic conditions

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dc.contributor.author Kresfelder, T.L.
dc.contributor.author Claassen, Nico
dc.contributor.author Cronje, M.J.
dc.date.accessioned 2007-05-18T12:45:22Z
dc.date.available 2007-05-18T12:45:22Z
dc.date.issued 2006-07
dc.description.abstract The possibility of using Hsp70 and hsp70 gene polymorphisms as markers of acclimatization was investigated. Volunteers (22) were subjected to an acclimatization regimen and blood analysed for Hsp70 (Hsp72) and hsp70 polymorphisms before and after a heat tolerance test. Physiological parameters denoting acclimatization, or not, were correlated to levels of Hsp70 and combination of hsp70 genes. Only individuals that acclimatized had decreased basal Hsp70 levels and increased ability to induce Hsp70 together with a specific hsp70 genotype combination. We propose that Hsp70 levels (basal vs. induced) with the genotype combination have the potential to be used as markers of acclimatization. en
dc.description.sponsorship National Research Foundation of SA and the Walker Fund of Faculty of Science, UJ for financial assistance. en
dc.format.extent 602972 bytes
dc.format.mimetype application/pdf
dc.identifier.citation Kresfelder, TL, Claassen, N & Cronje, MJ 2006. ‘Hsp70 induction and hsp70 gene polymorphisms as indicators of acclimatization under hyperthermic conditions’, Journal of Thermal Biology, vol. 31, issue 5, pp.406-415 [http://www.sciencedirect.com/science/journal/03064565] en
dc.identifier.issn 0306-4565
dc.identifier.issn 10.1016/j.jtherbio.2006.02.001
dc.identifier.uri http://hdl.handle.net/2263/2437
dc.language.iso en en
dc.publisher Elsevier en
dc.rights Elsevier en
dc.subject Heat shock proteins en
dc.subject Polymorphism en
dc.subject Acclimatize en
dc.subject Core temperature en
dc.subject Heat stroke en
dc.subject Hsp70 en
dc.subject Genotype combination en
dc.subject.lcsh Heat shock proteins
dc.subject.lcsh Genetic polymorphisms
dc.subject.lcsh Heat stroke
dc.title Hsp70 induction and hsp70 gene polymorphisms as indicators of acclimatization under hyperthermic conditions en
dc.type Postprint Article en


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