Please be advised that the site will be down for maintenance on Sunday, September 1, 2024, from 08:00 to 18:00, and again on Monday, September 2, 2024, from 08:00 to 09:00. We apologize for any inconvenience this may cause.
dc.contributor.author | Scriba, Thomas Jens![]() |
|
dc.contributor.author | Zur Megede, Jan![]() |
|
dc.contributor.author | Glashoff, Richard H.![]() |
|
dc.contributor.author | Treurnicht, Florette K.![]() |
|
dc.contributor.author | Barnett, Susan W.![]() |
|
dc.contributor.author | Janse van Rensburg, Estrelita![]() |
|
dc.date.accessioned | 2007-05-17T09:50:27Z | |
dc.date.available | 2007-05-17T09:50:27Z | |
dc.date.issued | 2005-01-19 | |
dc.description.abstract | The efficacy of cellular immune responses elicited by HIV vaccines is dependent on their strength, durability and antigenic breadth. The regulatory proteins are abundantly expressed early in the viral life cycle and CTL recognition may bring about early killing of infected cells. We synthesised DNA vaccine constructs that encode consensus HIV-1 subtype C Tat, Rev and Nef proteins. Proteins carrying inactivating mutations were tested for functional activity and highly expressing, inactive Tat, Rev and Nef mutants were identified and their reading frames fused into a TatRevNef cassette. Single- and polygene Tat, Rev and/or Nef constructs were immunogenic in BALB/c mice. These constructs may serve to increase the antigenic breadth for an HIV-1 vaccine that is relevant for sub-Saharan Africa. | en |
dc.format.extent | 458766 bytes | |
dc.format.mimetype | application/pdf | |
dc.identifier.citation | Scriba TJ, Zur Meged J, Glashoff RH, Treurnicht FK, Barnett SW, Janse van Rensburg E. Functionally-inactive and immunogenic Tat, Rev and Nef DNA vaccines derived from sub-Saharan subtype C human immunodeficiency virus type 1 consensus sequences. Vaccine. 2005 Jan 19; 23(9):1158-1169. [http://www.sciencedirect.com/science/journal/0264410X] | en |
dc.identifier.issn | 0264-410X | |
dc.identifier.other | 10.1016/j.vaccine.2004.08.026 | |
dc.identifier.uri | http://hdl.handle.net/2263/2421 | |
dc.language.iso | en | en |
dc.publisher | Elsevier | en |
dc.rights | Elsevier | en |
dc.subject.lcsh | HIV (Viruses) -- Sub-Saharan Africa | en |
dc.subject.lcsh | Genes | en |
dc.subject.lcsh | DNA vaccines -- Sub-Saharan Africa | en |
dc.subject.lcsh | Cellular immunity -- Sub-Saharan Africa | en |
dc.title | Functionally-inactive and immunogenic Tat, Rev and Nef DNA vaccines derived from sub-Saharan subtype C human immunodeficiency virus type 1 consensus sequences | en |
dc.type | Postprint Article | en |