Browsing Research Articles (Nuclear Medicine) by Title

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Browsing Research Articles (Nuclear Medicine) by Title

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  • The adjunctive use of carbimazole during radioactive iodine treatment reduces the cure rate of Graves’ disease 
    Docrat, F.; Mokoena, Taole; Karusseit, V.O.L. (Otto); Ankrah, Alfred O. (Health and Medical Publishing Group, 2021-02)
    BACKGROUND : Radioactive iodine (RAI) is widely used in the treatment of hyperthyroidism. Adjunctive antithyroid drugs (ATDs) are commonly prescribed to treat the hyperthyroid state before the RAI has taken effect. However, ...
  • Adjunctive use of statins for COVID-19 
    Sathekge, Mike Machaba; Byttebier, Geert; De Spiegeleer, Bart; Saxberg, Bo; Ueckermann, Veronica; Belmans, Luc; Alexander, Myriam; Fedson, David (MDPI, 2021-04-01)
    The interaction between obesity, cardiometabolic disorders and COVID-19 represents a syndemic that requires both social intervention and a multipharmacological approach. The risks associated with diabetes, obesity and ...
  • Advances in imaging of tuberculosis: the role of 18 F-FDG PET and PET/CT 
    Vorster, Mariza; Sathekge, Mike Machaba; Bomanji, Jamshed (Lippincott Williams and Wilkins, 2014-05)
    PURPOSE OF REVIEW : To review the main applications, advantages and limitations of 18F-FDG PET and PET/computed tomography (CT), and some other tracers in imaging of tuberculosis (TB). RECENT FINDINGS : In pulmonary TB, ...
  • Advances in PSMA alpha theragnostics 
    Vorster, Mariza; Sathekge, Mike Machaba (Elsevier, 2024-07)
    Alpha theranostics offer an attractive alternative form of therapy, which has best been investigated and documented with 225Ac-PSMA in patients with prostate cancer. Advantages offered by targeted alpha therapy include ...
  • Advances in radioligand theranostics in oncology 
    Lawal, Ismaheel Opeyemi; Abubakar, Sofiullah O.; Ndlovu, Honest; Mokoala, Kgomotso M.G.; More, Stuart; Sathekge, Mike Machaba (Springer, 2024-05)
    Please read abstract in the article.
  • Advances in targeted alpha therapy of cancer 
    Sathekge, Mike Machaba; Morgenstern, Alfred (Springer, 2024-04)
    No abstract available.
  • Analytical characterization of NOTA-modified somatropins 
    Bracke, Nathalie; Wynendaele, Evelien; D’Hondt, Matthias; Haselberg, Rob; Somsen, Govert W.; Pauwels, Ewald; Van de Wiele, Christophe; De Spiegeleer, Bart (Elsevier, 2014-08)
    Chemical modification of biomolecules like the introduction of metal-chelators into proteins can lead to heterogeneous product formation. The nature and extend of the modification is important in interpreting the biological ...
  • Antibiotic-derived radiotracers for positron emission tomography : nuclear or “unclear” infection imaging? 
    Gouws, Arno Christiaan; Kruger, Hendrik Gerhardus; Gheysens, Olivier; Zeevaart, Jan Rijn; Govender, Thavendran; Naicker, Tricia; Ebenhan, Thomas (Wiley, 2022-11)
    The excellent features of non-invasive molecular imaging, its progressive technology (real-time, whole-body imaging and quantification), and global impact by a growing infrastructure for positron emission tomography ...
  • Antimicrobial peptides : their role as infection-selective tracers for molecular imaging 
    Ebenhan, Thomas; Gheysens, Olivier; Kruger, Hendrik G.; Zeevaart, Jan Rijn; Sathekge, Mike Machaba (Hindawi Publishing, 2014-08)
    Antimicrobial peptides (AMPs) are a heterogeneous class of compounds found in a variety of organisms including humans and, so far, hundreds of these structures have been isolated and characterised. They can be described ...
  • Apoptosis imaging in oncology by means of positron emission tomography 
    Van de Wiele, Christophe; Ustmert, Sezgin; De Spiegeleer, Bart; De Jonghe, Pieter-Jan; Sathekge, Mike Machaba; Alex, Maes (MDPI Publishing, 2021-03-09)
    To date, a wide variety of potential PET-apoptosis imaging radiopharmaceuticals targeting apoptosis-induced cell membrane asymmetry and acidification, as well as caspase 3 activation (substrates and inhibitors) have been ...
  • Appropriate indications for positron emission tomography/computed tomography : college of nuclear physicians of the colleges of medicine of South Africa 
    Sathekge, Mike Machaba; Warwick, J.M.; Doruyter, A.; Vorster, Mariza (Health and Medical Publishing Group, 2015-11)
    Individualised patient treatment approaches demand precise determination of initial disease extent combined with early, accurate assessment of response to treatment, which is made possible by positron emission tomography/computed ...
  • Appropriate indications for positron emission tomography/computed tomography, 2015 
    Vorster, Mariza; Doruyter, A.; Brink, A.; Mkhize, S.; Holness, J.; Malan, N.; Nyakale, Nozipho E.; Warwick, J.M.; Sathekge, Mike Machaba (Health and Medical Publishing Group, 2016-01)
    These recommendations are intended to serve an important and relevant role in advising referring physicians on the appropriate use of 18F-fluorodeoxyglucose (18F-FDG) and non-18F-FDG positron emission tomography/computed ...
  • Article towards facile radiolabeling and preparation of gallium-68-/bismuth-213-dota-[thi8, met(O2)11]-substance p for future clinical application : first experiences 
    Suthiram, Janine; Ebenhan, Thomas; Marjanovic-Painter, Biljana; Sathekge, Mike Machaba; Zeevaart, Jan Rijn (MDPI, 2021-08)
    Please read abstract in the article.
  • Association between plasma homocysteine and myocardial SPECT abnormalities in patients referred for suspected myocardial ischaemia 
    Ankrah, Alfred O.; Buscombe, John Richard; Sathekge, Mike Machaba (Clinics Cardiv, 2012-07)
    BACKGROUND: Elevated plasma homocysteine level has emerged as a relatively newly recognised risk factor for coronary artery disease (CAD). However, reduction of plasma homocysteine levels in large prospective studies did ...
  • An automated synthesis method for 68Ga-labelled ubiquicidin 29–41 
    Le Roux, Jannie; Rubow, Sietke; Ebenhan, Thomas; Wagener, Carl (Springer, 2020-01)
    Published methods for radiolabelling of 1,4,7-triazacyclononane-1,4,7-triacetic acid ubiquicidin (NOTA-UBI) 29–41 to date describe manual or kit-based procedures. The purpose of this study was to develop an automated ...
  • Barriers and enablers for implementation of digital-linked diagnostics models at point-of-care in South Africa : stakeholder engagement 
    Moetlhoa, Boitumelo; Nxele, Siphesihle Robin; Maluleke, Kuhlula; Mathebula, Evans Mantiri; Marange, Musa; Chilufya, Maureen; Dzinamarira, Tafadzwa; Duah, Evans; Dzobo, Matthias; Kekana, Mable; Jaya, Ziningi Nobuhle; Thabane, Lehana; Dlangalala, Thobeka Nomzamo; Nyasulu, Peter S.; Hlongwana, Khumbulani; Dlungwane, Thembelihle; Kgatle, Mankgopo; Gxekea, Nobuhle; Mashamba‑Thompson, Tivani Phosa (BMC, 2024-02)
    The integration of digital technologies holds significant promise in enhancing accessibility to disease diagnosis and treatment at point-of-care (POC) settings. Effective implementation of such interventions necessitates ...
  • Biodistribution and pharmacokinetics of I-131 labelled 4-Iodophenylacetic acid 
    Zeevaart, Jan Rijn; Szucs, Zoltan; Pulker, Tamsyn A.; Sello, Thato; Bracher, Jacqueline; Sathekge, Mike Machaba (Bentham Science, 2012-10-11)
    Phenylacetate has been reported to have a potent anti-proliferative and anti-differentiating effect in haematological malignancies and in solid tumours at non-toxic concentrations. This study is a preliminary investigation ...
  • Biological characterisation of somatropin-derived cryptic peptides 
    Tack, Liesa; Bracke, Nathalie; Verbeke, Frederick; Wynendaele, Evelien; Pauwels, Ewald; Maes, Alex; Van de Wiele, Christophe; Sathekge, Mike Machaba; De Spiegeleer, Bart (Springer, 2019-09)
    Little is known about possible cryptic peptides of the recombinant growth hormone (somatropin). In this study, six synthetic somatropin-derived peptides (SDPs) were selected based on their sequences which correspond to the ...
  • Blood-brain barrier integrity in a zolpidem-responder patient 
    Nyakale, Nozipho E.; Clauss, Ralf P.; Nel, H.W.; Sathekge, Mike Machaba (Health and Medical Publishing Group, 2012-10)
    A 27-year-old neurologically disabled but fully conscious male zolpidem-responder patient was investigated for blood-brain barrier (BBB) dysfunction 5 years after a traumatic brain injury. A baseline single-photon ...
  • Burkitt lymphoma and cavernous sinus syndrome with breast uptake on 18F-FDG-PET/CT : a case report 
    Reyneke, Florette; Mokgoro, Neo P.; Vorster, Mariza; Sathekge, Mike Machaba (Lippincott, Williams and Wilkins, 2017)
    RATIONALE : Burkitt lymphoma (BL) is a type of non-Hodgkin lymphoma that arises in the B-cells. Cavernous sinus involvement is rare, especially in adults. Here we report an unusual case of a 30-year-old HIV-positive woman ...