Browsing Research Articles (Music) by Subject "Gametocytes"

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Browsing Research Articles (Music) by Subject "Gametocytes"

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  • Multistage antiplasmodium activity of astemizole analogues and inhibition of hemozoin formation as a contributor to their mode of action 
    Kumar, Malkeet; Okombo, John; Mambwe, Dickson; Taylor, Dale; Lawrence, Nina; Reader, Janette; Van der Watt, Mariette Elizabeth; Fontinha, Diana; Sanches-Vaz, Margarida; Bezuidenhout, Belinda C.; Lauterbach, Sonja B.; Liebenberg, Dale; Birkholtz, Lyn-Marie; Coetzer, Theresa L.; Prudêncio, Miguel; Egan, Timothy J.; Wittlin, Sergio; Chibale, Kelly (American Chemical Society, 2019-02)
    A drug repositioning approach was leveraged to derivatize astemizole (AST), an antihistamine drug whose antimalarial activity was previously identified in a high-throughput screen. The multistage activity potential against ...