Erythrocyte morphology and haemoglobin types of neonatal roan antelopes (Hippotragus equinus) with hypochromic poikilocytic anaemia

Show simple item record Parsons, S.D.C. Penzhorn, Barend Louis Reyers, Fred Steyl, Johan Christian Abraham Becker, Piet J. 2007-05-11T08:06:39Z 2007-05-11T08:06:39Z 2006
dc.description.abstract Neonatal, poikilocytic anaemia in some members of the Hippotragini has previously been documented but not fully investigated. This study was undertaken to describe the erythrocyte morphology of roan antelopes (Hippotragus equinus) during the first 4 weeks after birth and to identify aspects of haemoglobin (Hb) production that might be implicated in this syndrome. Twenty-nine roan antelope calves were sampled on, or close to, 1, 7, 14 and 28 days after birth. Erythrocyte morphology was characterized, and microhaematocrit values and Hb parameters determined, for each sampling occasion. Findings indicated a significant change in erythrocyte morphology during the neonatal period and two haemoglobin types, fetal and adult, were identified. The perinatal onset of adult Hb synthesis was delayed relative to the termination of fetal Hb production, resulting in the observed anaemia. Haemoglobin concentration and erythrocyte morphology were significantly correlated. These findings suggest an intimate relationship between Hb synthesis and the observed poikilocytosis. An imbalance in the synthesis of the α- and ß-globin chains of Hb (a thalassaemia) may prove to be the underlying pathophysiology of this syndrome. en
dc.description.sponsorship This work was supported by funding from the Faculty of Veterinary Science Research Committee, University of Pretoria (Protocol 36-5-624). The authors also thank Mr John Hume of Mauricedale Game Ranch for logistical and financial support, Mr Barry Gray of Bio-Rad Laboratories, South Africa for donating the VARIANT™ Hemoglobinopathy Program kit and Dr Emma Wypkema for logistical support from Lancet Laboratories, South Africa. We gratefully acknowledge the excellent technical assistance of Mrs Elsbé Myburgh and Mr Shafiek Shaikjee. en
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dc.format.mimetype application/pdf
dc.identifier.citation Parsons, SDC, Penzhorn, BL, Reyers, F, Steyl, JCA & Becker, PJ 2006. ‘Erythrocyte Morphology and Haemoglobin Types of Neonatal Roan Antelopes (Hippotragus equinus) with Hypochromic Poikilocytic Anaemia’, Journal of Comparative Pathology, vol. 134, issues 2-3, pp.152-160 [ ] en
dc.identifier.isbn 10.1016/j.jcpa.2005.09.008
dc.identifier.issn 0021-9975
dc.identifier.other 35609781000
dc.identifier.other J-7222-2013
dc.language.iso en en
dc.publisher Elsevier en
dc.rights Elsevier en
dc.subject Anaemia en
dc.subject Erythrocyte en
dc.subject Haemoglobin en
dc.subject Hippotragus equinus en
dc.subject Poikilocytosis en
dc.subject Roan antelope en
dc.subject.lcsh Wildlife diseases -- Molecular aspects en
dc.subject.lcsh Theileriosis en
dc.title Erythrocyte morphology and haemoglobin types of neonatal roan antelopes (Hippotragus equinus) with hypochromic poikilocytic anaemia en
dc.type Postprint Article en

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