Cryptococcus neoformans is the most common cause of laboratoryconfirmed
meningitis in South Africa.1 Despite the increased coverage of
antiretroviral treatment (ART), the country’s incidence of cryptococcal
meningitis remains high, and in routine care settings, the disease has a
case-fatality ratio of >50% at 12 weeks post-diagnosis.2-4 Screening and
pre-emptive antifungal treatment is desirable to prevent the development of
cryptococcal meningitis and associated deaths.