Comparison of pathogenic domains of rabies and African rabies-related lyssaviruses and pathogenicity observed in mice

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dc.contributor.author Kgaladi, Joe
dc.contributor.author Nel, Louis Hendrik
dc.contributor.author Markotter, Wanda
dc.date.accessioned 2013-05-29T06:52:20Z
dc.date.available 2013-05-29T06:52:20Z
dc.date.issued 2013-03-08
dc.description Scan this QR code with your smart phone or mobile device to read online. en_US
dc.description W.M. (University of Pretoria) was the project leader, L.H.N. (University of Pretoria) the project co-leader and J.K. (University of Pretoria) performed the experiments. All authors contributed to writing the manuscript. en_US
dc.description.abstract Several lyssavirus species occur in Africa (Rabies virus, Lagos bat virus, Mokola virus, Duvenhage virus, Shimoni bat virus and Ikoma lyssavirus), displaying a high sequence diversity between isolates belonging to the same species. There is limited information about comparative pathogenesis of these African lyssaviruses and this precludes authoritative opinion on the potential public and veterinary health impact. In this study, an analysis of representative African lyssaviruses attempted to correlate viral genomic sequence similarities and differences with the corresponding pathogenic profiles observed in mice. The study demonstrated that the virus isolates evaluated could be lethal to mice when introduced intramuscularly and that different isolates of the same lyssavirus species differ in their virulence. Using real-time polymerase chain reaction (PCR), viral RNA was detected in brain tissue, but no viral RNA was detected in the salivary glands or blood of mice that succumbed to infection. Comparison of known pathogenic domains indicated that pathogenicity is likely to be dependent on multiple domains. Cumulatively, our results re-emphasised the realisation that the pathogenicity of a lyssavirus species cannot be deduced based on studies of only a single isolate of the species or a single pathogenic domain. en_US
dc.description.librarian am2013 en_US
dc.description.sponsorship We thank the National Research Foundation, the International Society for Infectious Diseases, the International Foundation for Science and the Poliomyelitis Research Foundation for financial support. en_US
dc.description.uri http://www.ojvr.org en_US
dc.identifier.citation Kgaladi, J., Nel, L.H. & Markotter, W., 2013, ‘Comparison of pathogenic domains of rabies and African rabies-related lyssaviruses and pathogenicity observed in mice’, Onderstepoort Journal of Veterinary Research 80(1), Art. #511, 13 pages.http://dx.DOI.org/ 10.4102/ojvr.v80i1.511 en_US
dc.identifier.issn 0030-2465 (print)
dc.identifier.issn 2219-0635 (online)
dc.identifier.other 10.4102/ojvr.v80i1.511
dc.identifier.uri http://hdl.handle.net/2263/21553
dc.language.iso en en_US
dc.publisher AOSIS Open Journals en_US
dc.rights © 2013. The Authors. Licensee: AOSIS OpenJournals. This work is licensed under the Creative Commons Attribution License. en_US
dc.subject Mice en_US
dc.subject Rabies en_US
dc.subject African rabies-related lyssaviruses en_US
dc.subject Pathogenicity en_US
dc.title Comparison of pathogenic domains of rabies and African rabies-related lyssaviruses and pathogenicity observed in mice en_US
dc.type Article en_US


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