Pathogen- and host-directed anti-inflammatory activities of macrolide antibiotics

Show simple item record Steel, Helen C. Theron, Annette J. Cockeran, Riana Anderson, Ronald Feldman, Charles
dc.contributor.editor Asano, Kazuhito 2013-04-19T09:02:23Z 2013-04-19T09:02:23Z 2012
dc.description.abstract Macrolide antibiotics possess several, beneficial, secondary properties which complement their primary antimicrobial activity. In addition to high levels of tissue penetration, whichmay counteract seemingly macrolide-resistant bacterial pathogens, these agents also possess anti-inflammatory properties, unrelated to their primary antimicrobial activity. Macrolides target cells of both the innate and adaptive immune systems, as well as structural cells, and are beneficial in controlling harmful inflammatory responses during acute and chronic bacterial infection. These secondary anti-inflammatory activities of macrolides appear to be particularly effective in attenuating neutrophil-mediated inflammation. This, in turn, may contribute to the usefulness of these agents in the treatment of acute and chronic inflammatory disorders of both microbial and nonmicrobial origin, predominantly of the airways. This paper is focused on the various mechanisms of macrolide-mediated anti-inflammatory activity which target both microbial pathogens and the cells of the innate and adaptive immune systems, with emphasis on their clinical relevance. en_US
dc.description.librarian am2013 en_US
dc.description.uri en_US
dc.format.extent 17 pages en_US
dc.format.medium PDF en_US
dc.identifier.citation Steel, HC, Theron, AJ, Cockeran, R, Anderson, R & Feldman, C 2012, 'Pathogen- and host-directed anti-inflammatory activities of macrolide antibiotics', Mediators of Inflammation, vol. 2012, no. 584262, pp. 1-17. en_US
dc.identifier.issn 0962-9351 (print)
dc.identifier.issn 1466-1861 (online)
dc.identifier.other 10.1155/2012/584262
dc.language.iso en en_US
dc.publisher Hindawi Publishing Corporation en_US
dc.rights © 2012 Helen C. Steel et al. This is an open access article distributed under the Creative Commons Attribution License en_US
dc.subject Macrolide antibiotics en_US
dc.subject Anti-inflammatory properties en_US
dc.title Pathogen- and host-directed anti-inflammatory activities of macrolide antibiotics en_US
dc.type Article en_US

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