Carotid intima-media thickness and its associations with type 2 diabetes mellitus in South Africans

Show simple item record Rheeder, Paul Duim-Beytell, M.C. Meijer, R. Gustavsson, T. Danler, G.K.G. Ahmed, R.A. Van Zyl, Danie G. 2013-01-31T13:11:35Z 2013-01-31T13:11:35Z 2012
dc.description.abstract OBJECTIVES: Carotid intima-media thickness (CIMT) is a surrogate marker of subclinical atherosclerosis and a predictor of cardiovascular events. Few studies in Africa have evaluated CIMT and its associations in people with type 2 diabetes mellitus. This study measured CIMT in a sample of mainly black South African patients with type 2 diabetes mellitus, and evaluated the association of demographic and clinical risk factors with CIMT. DESIGN: Cross-sectional study. SETTING: Kafalong Hospital, a large community hospital in Pretoria that mainly serves an urban black community. SUBJECTS: Patients with type 2 diabetes mellitus. OUTCOME MEASURES: We evaluated clinical, biochemical and CIMT ultrasound measurements in a standardised fashion. RESULTS: In 185 patients, the univariate significant predictors of mean far-wall CIMT were age [beta 0.007 (standard error 0.001)], systolic blood pressure [beta 0.001 (standard error 0.000)] and inverse serum creatinine [beta -8.15 (standard error 3.23)]. Low-density lipoprotein cholesterol, apolipoprotein A-1, apolipoprotein B:A-1 ratio and apolipoprotein B:A-1 ratio > 1.2 all had p-values below 0.1, but above 0.05. Age had the largest R-squared (20%). The multivariate models did not explain more of the variation in CIMT than did age alone. CONCLUSION: Lipid parameters were related to CIMT in our study population. However, this did not reach statistical significance in this relatively small sample, and lipids added very little to the variability of CIMT compared with age alone. en_US
dc.description.librarian ay2013 en
dc.description.uri en_US
dc.identifier.citation Rheeder, P, Duim-Beytell, MC, Meijer, R, Gustavsson, T, Danler, GKG, Ahmed, RA & Van Zyl, DG 2012, 'Carotid intima-media thickness and its associations with type 2 diabetes mellitus in South Africans', Journal of Endocrinology, Metabolism & Diabetes of South Africa, vol. 17, no. 3, pp. 135-140. en_US
dc.identifier.issn 1608-9677
dc.language.iso en en_US
dc.publisher Medpharm Publications en_US
dc.rights © SEMDSA en_US
dc.subject Carotid intima-media thickness en_US
dc.subject Diabetes mellitus en_US
dc.subject Blacks en_US
dc.subject Apolipoproteins en_US
dc.subject Low-density lipoprotein en_US
dc.subject High-density lipoprotein en_US
dc.subject Cystatin C en_US
dc.subject.lcsh Diabetes -- Complications -- South Africa en
dc.title Carotid intima-media thickness and its associations with type 2 diabetes mellitus in South Africans en_US
dc.type Article en_US

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