Beta-2 microglobulin as a predictor of peripheral arterial disease in diabetes : the effect of estimated glomerular filtration

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dc.contributor.author Rheeder, Paul
dc.contributor.author Nel, L.
dc.contributor.author Meeuws, F.
dc.contributor.author Van Schendel, M.
dc.contributor.author Meyer, P.W.A. (Pieter Willem Adriaan)
dc.date.accessioned 2013-01-31T13:10:43Z
dc.date.available 2013-01-31T13:10:43Z
dc.date.issued 2012
dc.description.abstract BACKGROUND: Peripheral arterial disease (PAD) is common in patients with type 2 diabetes mellitus. Its definitive diagnosis requires ultrasound or angiography. Beta-2 microglobulin (β2 microglobulin) has been proposed as a diagnostic marker for PAD. The objective of the study was to evaluate the diagnostic value of β2 microglobulin for PAD in patients with diabetes and varying renal function. DESIGN: This was a cross-sectional study. SETTING: An academic centre (University of Pretoria and Steve Biko Academic Hospital Diabetes Clinic). SUBJECTS: One hundred and eight convenience-sampled patients. OUTCOME MEASURES: Patients completed a questionnaire and had toe and arm blood pressure (toe-arm index), as well as serum β2 microglobulin and creatinine, measured. RESULTS: Beta-2 microglobulin did not differ (p-value = 0.34) between those subjects with PAD (n = 43) and those without PAD (n = 65). In a linear regression model, the interaction term between estimated glomerular filtration rate categories and the inverse of β2 microglobulin was highly significant (p-value = 0.001). CONCLUSION: Although the sample size was small, β2 microglobulin did not distinguish between subjects with and without PAD. Renal function and its effects on the association between β2 microglobulin and PAD need further study. en_US
dc.description.librarian am2013 en_US
dc.description.librarian ay2013 en
dc.description.uri http://www.jemdsa.co.za/index.php/JEMDSA en_US
dc.identifier.citation Rheeder, P, Nel. L, Meeuws, F., Van Schendel, M & Meyer, PWA 2012, 'Beta-2 microglobulin as a predictor of peripheral arterial disease in diabetes : the effect of estimated glomerular filtration', Journal of Endocrinology, Metabolism & Diabetes of South Africa, vol. 17, no. 3, pp. 141-144. en_US
dc.identifier.issn 1608-9685
dc.identifier.uri http://hdl.handle.net/2263/20915
dc.language.iso en en_US
dc.publisher Medpharm Publications en_US
dc.rights © SEMDSA en_US
dc.subject Peripheral arterial disease en_US
dc.subject Diabetes en_US
dc.subject Mellitus en_US
dc.subject β2 microglobulin en_US
dc.subject.lcsh Diabetes -- Research en
dc.subject.lcsh Arteries -- Diseases -- South Africa en
dc.title Beta-2 microglobulin as a predictor of peripheral arterial disease in diabetes : the effect of estimated glomerular filtration en_US
dc.type Article en_US


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