Exaggerated circulating Th-1 cytokine response in early rheumatoid arthritis patients with nodules

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dc.contributor.author Hodkinson, Bridget
dc.contributor.author Meyer, P.W.A. (Pieter Willem Adriaan)
dc.contributor.author Musenge, Eustasius
dc.contributor.author Ally, Mahmood Moosa Tar Mahomed
dc.contributor.author Anderson, Ronald
dc.contributor.author Tikly, Mohammed
dc.date.accessioned 2012-12-12T11:23:42Z
dc.date.available 2012-12-12T11:23:42Z
dc.date.issued 2012-11
dc.description.abstract BACKGROUND: Immunohistochemical studies of the rheumatoid nodule (RN) suggest it is a Th1 granuloma, with focal vasculitis, yet the pathogenesis remains unclear and little is known about circulating cytokines in these patients. OBJECTIVE: We studied circulating cytokines in DMARD-naïve RA patients to investigate associations with subcutaneous RN. METHODS: 149 DMARD-naïve adults with early RA (symptom duration 62 years) were assessed using the Simplified Disease Activity Index (SDAI), and hand and feet radiographs were scored using the modified Larsen method. Circulating cytokines and growth factors representative of T-helper cell 1(Th1) and Th2 cell, macrophages, and fibroblasts were measured using the Bio-Plex suspension array system. RESULTS: Of 149 patients, 34 (22.8%) had subcutaneous RN, and these patients had more severe disease with higher mean swollen joint counts (p = 0.02), SDAI (p = 0.04) and modified Larsen scores (p = 0.004). There were no differences in Rheumatoid Factor or anti-cyclic citrullinated peptide antibody positivity between patients with RN and those without RN. Patients with RN showed significantly higher levels of circulating IL-12 (p = 0.02), IL-2 (p = 0.048), and VEGF (p = 0.033) levels, with a trend towards higher levels of IL-7 (p = 0.056), IFN-c (p = 0.059) and IL-8 (p = 0.074) compared to those without RN. CONCLUSIONS: DMARD-naïve early RA patients with RN had more severe disease than those without RN, and showed an exaggerated circulating Th1 and macrophage cytokine profile. en_US
dc.description.sponsorship The Connective Tissue Diseases Research Fund, University of the Witwatersrand and the Medical Research Council of South Africa. en_US
dc.description.uri http://www.journals.elsevier.com/cytokine/ en_US
dc.identifier.citation B. Hodkinson, P.W.A. Meyer, E. Musenge, M. Ally, R. Anderson & M. Tikly, Exaggerated circulating Th-1 cytokine response in early rheumatoid arthritis patients with nodules, Cytokine, vol. 60, no. 2, pp. 561-564 (2012), doi: 10.1016/j.cyto.2012.06.190 en_US
dc.identifier.issn 1043-4666 (print)
dc.identifier.issn 1096-0023 (online)
dc.identifier.other 10.1016/j.cyto.2012.06.190
dc.identifier.uri http://hdl.handle.net/2263/20790
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.rights © 2012 Elsevier. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Cytokine. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Cytokine, vol 60, issue 2, November 2012, doi: 10.1016/j.cyto.2012.06.190. en_US
dc.subject Extra-articular disease en_US
dc.subject Circulating cytokines en_US
dc.subject VEGF en_US
dc.subject Rheumatoid nodule (RN) en_US
dc.title Exaggerated circulating Th-1 cytokine response in early rheumatoid arthritis patients with nodules en_US
dc.type Postprint Article en_US


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