Functional disability and health-related quality of life in South Africans with early rheumatoid arthritis

Show simple item record

dc.contributor.author Hodkinson, Bridget
dc.contributor.author Musenge, Eustasius
dc.contributor.author Ally, Mahmood Moosa Tar Mahomed
dc.contributor.author Meyer, P.W.A. (Pieter Willem Adriaan)
dc.contributor.author Anderson, Ronald
dc.contributor.author Tikly, Mohammed
dc.date.accessioned 2012-12-12T11:18:48Z
dc.date.available 2013-10-31T00:20:04Z
dc.date.issued 2012-10
dc.description.abstract BACKGROUND: The severity and predictors of functional disability and health-related quality of life (HRQoL) in a cohort of South Africans with early RA were investigated. METHODS: Changes in the Health Assessment Questionnaire-disability index (HAQ) and the Short Form-36 (SF-36) following 12 months of traditional disease modifying anti-rheumatic drugs (DMARDs) were studied in previously DMARD-naïve adults with disease duration ≤ 2 years. RESULTS: The majority of the 171 patients were female (82%), black Africans (89%) with a mean (SD) symptom duration of 11.6 (7.0) months. In the 134 patients seen at 12 months, there were significant improvements in the HAQ and all domains of the SF-36, but 92 (69%) still had substantial functional disability (HAQ >0.5), and 89 (66%) had suboptimal mental health (SF-36 mental composite score <66.6). Multivariate analysis showed that female sex (p=0.05) and high baseline HAQ (p<0.01) predicted substantial functional disability at 12 months. Unemployment (p=0.03), high baseline pain (p=0.02) and HAQ (p=0.04) predicted suboptimal mental health, with a trend towards low level of schooling being significant (p=0.08). CONCLUSIONS: Early RA has a broad impact on HRQoL in indigent South Africans, with a large proportion of patients still showing substantial functional disability and suboptimal mental health despite 12 months of DMARD therapy. Further research is needed to establish the role of interventions including psycho-social support, rehabilitation programmes and biologic therapy to improve physical function and HRQoL in this population. en_US
dc.description.sponsorship The Connective Tissue Diseases Research Fund, University of the Witwatersrand and the Medical Research Council of South Africa. en_US
dc.description.uri http://informahealthcare.com/journal/rhe en_US
dc.identifier.citation Hodkinson, B, Musenge, E, Ally, A, Meyer, PWA, Anderson, R & Tikly, M 2012, 'Functional disability and health-related quality of life in South Africans with early rheumatoid arthritis', Scandinavian Journal of Rheumatology, vol. 41, no. 5, pp. 366-374. en_US
dc.identifier.issn 0300-9742 (print)
dc.identifier.issn 1502-7732 (online)
dc.identifier.other 10.3109/03009742.2012.676065
dc.identifier.uri http://hdl.handle.net/2263/20787
dc.language.iso en en_US
dc.publisher Informa Healthcare en_US
dc.rights Informa Healthcare. This is an electronic version of the article: Hodkinson, B, Musenge, E, Ally, A, Meyer, PWA, Anderson, R & Tikly, M 2012, 'Functional disability and health-related quality of life in South Africans with early rheumatoid arthritis', Scandinavian Journal of Rheumatology, vol. 41, no. 5, pp. 366-374. Scandinavian Journal of Rheumatology is available online at http://informahealthcare.com/journal/rhe en_US
dc.subject Functional disability en_US
dc.subject Health-related quality of life en_US
dc.subject South Africa en_US
dc.subject Socio-economic status en_US
dc.subject Rheumatoid arthritis (RA) en_US
dc.subject Medical rehabilitation en_US
dc.title Functional disability and health-related quality of life in South Africans with early rheumatoid arthritis en_US
dc.type Postprint Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record