Assessment of renal dysfunction using urinary markers in canine babesiosis caused by Babesia rossi

Show simple item record Defauw, P. Schoeman, Johan P. Smets, P. Goddard, Amelia Meyer, E. Liebenberg, C. Daminet, S. 2012-12-12T06:56:35Z 2012-12-12T06:56:35Z 2012-12-21
dc.description.abstract Renal damage is deemed a common, yet poorly documented, complication in canine babesiosis. Serum urea and creatinine are insensitive and non-specific markers of early renal dysfunction and their measurements are influenced by hemolysis caused by babesiosis. Therefore, the aim of this study was to use urinary markers to assess the localization and degree of renal dysfunction in dogs with Babesia rossi infection. Urinary immunoglobulin G (uIgG) and urinary C-reactive protein (uCRP) were measured as markers for glomerular dysfunction, while urinary retinol-binding protein (uRBP) was used as a marker for tubular dysfunction. Eighteen dogs presenting with uncomplicated babesiosis were included and compared with eight clinically healthy dogs. Previously validated commercial ELISA kits were used for the measurement of uIgG, uCRP, and uRBP. Results were related to urinary creatinine concentrations (c). Dogs with babesiosis had significantly higher concentrations of all three measured urinary markers compared to healthy dogs. Except for urinary protein/c ratio (UPC), routine urinary and serum markers for renal function (urine specific gravity (USG), serum urea and creatinine (sCr)) were not significantly different between dogs with babesiosis and healthy dogs. All three urinary markers were positively correlated with each other and with UPC. The data supports the presence of both glomerular and tubular dysfunction in dogs suffering from uncomplicated B. rossi infection. Urinary markers were superior to USG, serum urea and creatinine concentrations for the early detection of renal dysfunction in dogs with babesiosis. en_US
dc.description.uri en_US
dc.identifier.citation P. Defauw, J.P. Schoeman, P. Smets, A. Goddard, E. Meyer, C. Liebenberg & S. Daminet, Assessment of renal dysfunction using urinary markers in canine babesiosis caused by Babesia rossi, Veterinary Parasitology, vol. 190, no. 3-4, pp. 326-332 (2012), doi: 10.1016/j.vetpar.2012.07.023 en_US
dc.identifier.issn 0304-4017 (print)
dc.identifier.issn 1873-2550 (online)
dc.identifier.other 10.1016/j.vetpar.2012.07.023
dc.identifier.other 55546522700
dc.identifier.other 7005814117
dc.identifier.other J-6765-2013
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.rights © 2012 Elsevier. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Veterinary Parasitology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Veterinary Parasitology, vol 190, issue 3-4, 21 December 2012, doi: 10.1016/j.vetpar.2012.07.023. en_US
dc.subject Babesiosis en_US
dc.subject Dogs en_US
dc.subject Renal dysfunction en_US
dc.subject C-reactive protein en_US
dc.subject Immunoglobulin G en_US
dc.subject Retinol-binding protein en_US
dc.title Assessment of renal dysfunction using urinary markers in canine babesiosis caused by Babesia rossi en_US
dc.type Postprint Article en_US

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