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| dc.contributor.author | Botha, C.J. (Christoffel Jacobus)
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| dc.contributor.author | Gehring, Ronette
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| dc.contributor.author | Van Rooyen, J.M.
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| dc.contributor.author | Venter, D.
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| dc.contributor.editor | Boomker, Jacob Diederik Frederik | |
| dc.date.accessioned | 2012-12-12T06:47:40Z | |
| dc.date.available | 2012-12-12T06:47:40Z | |
| dc.date.created | 2012 | |
| dc.date.issued | 2002 | |
| dc.description | The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat v.9 was used to OCR the text and also for the merging and conversion to the final presentation PDF-format. | en_US |
| dc.description.abstract | Three cardiac glycosides were screened for pharmacological effects on isolated rat jejunum. The contraction of rat jejunum with epoxyscillirosidin, a non-cumulative bufadienolide, and cotyledoside and tyledoside D, both cumulative neurotoxic bufadienolides were compared with methacholine. The results indicate that all three bufadienolides cause contraction of jejunal smooth muscle. When combined with atropine (1X10ˉ⁶ M) the response of epoxyscillirosidin and tyledoside D decreased, indicating suppression of a cholinergic response caused by the cardiac glycosides. | en_US |
| dc.identifier.citation | Botha, CJ, Gehring, R, Van Rooyen, JM & Venter, D 2002, 'The effect of three bufadienolide cardiac glycosides on contraction of isolated rat jejunum’. Onderstepoort Journal of Veterinary Research, vol. 69, no. 3, pp. 243-246. | en_US |
| dc.identifier.issn | 0030-2465 | |
| dc.identifier.other | 7006558662 | |
| dc.identifier.other | O-5991-2014 | |
| dc.identifier.uri | http://hdl.handle.net/2263/20694 | |
| dc.language | en | |
| dc.publisher | Published jointly by the Agricultural Research Council, ARC-Onderstepoort Veterinary Institute and the Faculty of Veterinary Science, University of Pretoria. | en_US |
| dc.rights | © ARC-Onderstepoort and Faculty of Veterinary Science, University of Pretoria (original). © University of Pretoria. Dept of Library Services (digital). | en_US |
| dc.subject | Veterinary medicine | en_US |
| dc.subject | Bufadienolide | en_US |
| dc.subject | Cardiac glycosides | en_US |
| dc.subject | Cotyledoside | en_US |
| dc.subject | Epoxyscillirosidin | en_US |
| dc.subject | Methacholine | en_US |
| dc.subject | Rat jejunum | en_US |
| dc.subject | Tyledoside D | en_US |
| dc.subject.lcsh | Veterinary medicine -- South Africa | |
| dc.title | The effect of three bufadienolide cardiac glycosides on contraction of isolated rat jejunum | en_US |
| dc.type | Article | en_US |
