Distribution of horizontally transferred heavy metal resistance operons in recent outbreak bacteria

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dc.contributor.author Reva, Oleg N.
dc.contributor.author Bezuidt, K.I.O. (Keoagile Ignatius Oliver)
dc.date.accessioned 2012-11-20T11:54:21Z
dc.date.available 2013-03-31T00:20:04Z
dc.date.issued 2012-03
dc.description.abstract Mankind is confronted by the outbreaks of highly virulent and multi-drug resistant pathogens. The outbreak strains often belong to wellknown disease-associated species belonging to genera such as Salmonella, Klebsiella and Mycobacterium, but even normally commensal and environmental microorganisms may suddenly acquire properties of virulent bacteria and cause nosocomial infections. The acquired virulence is often associated with lateral exchange of pathogenicity genomic islands containing drug and heavy metal resistance determinants. Metal ions are used by the immune system of macroorganisms against bactericidal agents. The ability to control heavy metal homeostasis is a factor that allows the survival of pathogenic microorganisms in macrophages. In this paper, we investigate the origin of heavy metal resistance operons in the recent outbreak strains and the possible routes which may lead to acquisitions of these genes by potentially new pathogens. We hypothesize that new outbreak microorganisms appear intermittently on an intersection of the nonspecialized, genetically naïve strains of potential pathogens and virulence factor comprising vectors (plasmid and/or phages) newly generated in the environmental microflora. Global contamination of the environment and climate change may also have an effect toward the acceleration and appearance of new pathogens. en_US
dc.description.sponsorship The National Research Foundation of South Africa grant NRF 71261. en_US
dc.description.uri http://www.landesbioscience.com/journals/mge/ en_US
dc.identifier.citation Reva, ON & Bezuidt, O 2012, 'Distribution of horizontally transferred heavy metal resistance operons in recent outbreak bacteria', Mobile Genetic Elements, vol. 2, no. 2, pp. 96-100. en_US
dc.identifier.issn 2159-2543 (print)
dc.identifier.issn 2159-256X (online)
dc.identifier.other 10.4161/mge.19963
dc.identifier.uri http://hdl.handle.net/2263/20454
dc.language.iso en en_US
dc.publisher Landes Bioscience en_US
dc.rights © 2012 Landes Bioscience. en_US
dc.subject Horizontal gene transfer en_US
dc.subject Heavy metal resistance en_US
dc.subject Virulence en_US
dc.subject Outbreak en_US
dc.title Distribution of horizontally transferred heavy metal resistance operons in recent outbreak bacteria en_US
dc.type Postprint Article en_US


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