The use of natural honey (NH) as a nutraceutical agent is associated with nutritional benefits and therapeutic
promises. NH is widely accepted as food and medicine by all generations, traditions and civilizations, both ancient
and modern. The nutritional profiles, including its use in infant and children feeding reported in different literatures
as well as health indices and biomarkers observed by various researchers are illustrated in this manuscript. The
review documents folk medicine, experimentation with animal models, and orthodox medical practices shown by
clinical trials. This covers virtually all human organs and body systems extensively studied by different workers.
The sources and adverse effects of NH contamination, as well as the preventive methods are identified. This could
promote the availability of residue free honey and a wholesome natural product for domestic consumption and
international market. This could also help to prevent health problems associated with NH poisoning. In addition,
apicultural practices and the economic importance of honey are well documented. This report also includes
information about a relatively unknown and uncommon South American stingless bee species. We concluded this
review by identifying important roles for Ethno-entomologists, other Scientists and Apiculturists in the development
of stingless bees to boost honey production, consumption and economic earnings.