Seroprevalence of Crimean Congo hemorrhagic fever virus in Ijara District, Kenya

Show simple item record Lwande, Olivia Wesula Irura, Zephania Tigoi, Caroline Chepkorir, Edith Orindi, Benedict Musila, Lillian Venter, Marietjie Fischer, Anne Sang, Rosemary 2012-10-22T07:14:41Z 2012-10-22T07:14:41Z 2012
dc.description.abstract Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral disease mainly affecting pastoralists who come in contact with animals infested with Hyalomma ticks, which are the key vectors of CCHF virus (CCHFV). CCHFV has been detected among these ticks in parts of North Eastern Kenya. This study aimed to identify acute cases of CCHF, and to determine the extent of previous exposure to CCHFV in an outpatient population attending Sangailu and Ijara health centers, Ijara District, North Eastern Kenya, presenting with acute febrile illnesses. A total of 517 human serum samples were collected from these patients. The samples were screened for the presence of IgM and IgG antibodies to CCHF using CCCHF-IgG and IgM ELISA test kits. A multivariable logistic regression model was used to investigate the risk factors associated with evidence of exposure to CCHFV. A single patient tested positive for anti-CCHF IgM, while 96 were positive for anti-CCHF IgG. The seroprevalence of CCHFV was 23% in Sangailu and 14% in Ijara. Most exposed persons were aged 40–49 years. The likelihood of exposure was highest among farmers (29%). Age, location, and contact with donkeys were significantly associated with exposure to CCHFV. Acute CCHFV infections could be occurring without being detected in this population. This study confirms human exposure to CCHF virus in Ijara District, Kenya, and identifies several significant risk factors associated with exposure to CCHFV. en_US
dc.description.sponsorship, the philanthropic arm of Google. en_US
dc.description.uri en_US
dc.identifier.citation Lwande, WL, Irura, Z, Tigoi, C, Chepkorir, B, Orindi, B, Musila, L, Venter, M, Fischer, A & Sang, R 2012, 'Seroprevalence of Crimean Congo hemorrhagic fever virus in Ijara District, Kenya', Vector Borne and Zoonotic Diseases, vol. 12, no. 9, pp. 727-732. en_US
dc.identifier.issn 1530-3667
dc.identifier.other 10.1089/vbz.2011.0914
dc.language.iso en en_US
dc.publisher Mary Ann Liebert en_US
dc.rights © Mary Ann Liebert, Inc. This is a copy of an article published in the Vector Borne and Zoonotic Diseases, Volume 12, Number 9, 2012 ; Vector Borne and Zoonotic Diseases is available online at: en_US
dc.subject Hyalomma en_US
dc.subject Ticks en_US
dc.subject Ijara District, Kenya en_US
dc.subject Crimean-Congo hemorrhagic fever (CCHF) en_US
dc.subject.lcsh Hemorrhagic fever en
dc.title Seroprevalence of Crimean Congo hemorrhagic fever virus in Ijara District, Kenya en_US
dc.type Article en_US

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