Towards understanding the functional diversity of cell wall mycolic acids of Mycobacterium tuberculosis

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dc.contributor.author Verschoor, J.A. (Jan Adrianus), 1953-
dc.contributor.author Baird, Mark S.
dc.contributor.author Grooten, Johan
dc.date.accessioned 2012-10-10T11:54:15Z
dc.date.available 2012-10-10T11:54:15Z
dc.date.issued 2012-10
dc.description.abstract Mycolic acids constitute the waxy layer of the outer cell wall of Mycobacterium spp and a few other genera. They are diverse in structure, providing a unique chromatographic foot-print for almost each of the more than seventy Mycobacterium species. Although mainly esterified to cell wall arabinogalactan, trehalose or glucose, some free mycolic acid is secreted during in vitro growth of M. tuberculosis. In M. tuberculosis, alpha-, keto- and methoxy-mycolic acids are the main classes, each differing in their ability to attract neutrophils, induce foamy macrophages or adopt an antigenic structure for antibody recognition. Of interest is their particular relationship to cholesterol, discovered by their ability to attract cholesterol, to bind Amphotericin B or to be recognised by monoclonal antibodies that cross-react with cholesterol. The structural elements that determine this diverse functionality include the carboxylic acid in the mycolic motif, as well as the nature and stereochemistry of the two functional groups in the merochain. The functional diversity of mycolic acid classes implies that much information may be contained in the selective expression and secretion of mycolic acids to establish tuberculosis after infection of the host. Their cholesteroid nature may relate to how they utilize host cholesterol for their persistent survival. en
dc.description.librarian nf2012 en
dc.description.sponsorship South African National Research Foundation en_US
dc.description.uri http://www.elsevier.com/locate/plipres en_US
dc.identifier.citation Verschoor, JA, Baird, MS & Grooten, J 2012, 'Towards understanding the functional diversity of cell wall mycolic acids of Mycobacterium tuberculosis', Progress in Lipid Research, vol. 51, no. 4, pp. 325-339, doi:10.1016/j.plipres.2012.05.002 en
dc.identifier.issn 0163-7827 (print)
dc.identifier.issn 1873-2194 (online)
dc.identifier.other 10.1016/j.plipres.2012.05.002
dc.identifier.uri http://hdl.handle.net/2263/20099
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.rights © 2012 Elsevier. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Progress in Lipid Research. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Progress in Lipid Research, vol 51, issue 4, October 2012, doi: 10.1016/j.pilpres.2012.05.022. en_US
dc.subject Mycolic acid motif en
dc.subject Foamy macrophages en
dc.subject Antigenicity en
dc.subject.lcsh Cholesterol en
dc.subject.lcsh Mycobacterium tuberculosis en
dc.subject.lcsh Tuberculosis -- Microbiology en
dc.subject.lcsh Bacterial cell walls en
dc.title Towards understanding the functional diversity of cell wall mycolic acids of Mycobacterium tuberculosis en
dc.type Postprint Article en


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