Browsing Research Articles (Mathematics and Applied Mathematics) by Author "Mahasa, Khaphetsi Joseph"

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Mesenchymal stem cells used as carrier cells of oncolytic adenovirus results in enhanced oncolytic virotherapy

Mahasa, Khaphetsi Joseph; De Pillis, Lisette; Ouifki, Rachid; Eladdadi, Amina; Maini, Philip; Yoon, A-Rum; Yun, Chae-Ok (Nature Publishing Group, 2020-01-16)

Mesenchymal stem cells (MSCs) loaded with oncolytic viruses are presently being investigated as a new modality of advanced/metastatic tumors treatment and enhancement of virotherapy. MSCs can, however, either promote or ...
Oncolytic potency and reduced virus tumorspecificity in oncolytic virotherapy : a mathematical modelling approach

Mahasa, Khaphetsi Joseph; Eladdadi, Amina; De Pillis, Lisette; Ouifki, Rachid (Public Library of Science, 2017-09-21)

In the present paper, we address by means of mathematical modeling the following main question: How can oncolytic virus infection of some normal cells in the vicinity of tumor cells enhance oncolytic virotherapy? We ...

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