Agomelatine : a review for general practitioners

Show simple item record Outhoff, Kim 2012-08-07T07:01:27Z 2012-08-07T07:01:27Z 2012
dc.description.abstract Agomelatine is a novel melatonergic antidepressant that restores disrupted biological rhythms, essentially by resetting the circadian clock. Two different, non-monoaminergic, and possibly synergistic pathways, appear to be involved in its mechanism of action. Agomelatine is a melatonin 1 (MT1) and melatonin 2 (MT2) receptor agonist and serotonin (5-hydroxytryptamine) 2C (5-HT2C) receptor antagonist. It is effective in treating moderate-to-severe depression, alleviating the symptoms of anxiety, and restoring the disrupted sleep patterns that often result from this potentially devastating disease. Agomelatine is generally well tolerated with little, if any, propensity for antidepressant-induced sexual dysfunction, weight gain, or discontinuation reactions. However, it has the potential to cause temporary hepatotoxicity, and liver functions need to be monitored as a result. Clinically, meaningful drug interactions are unlikely, with the exception of co-administered potent cytochrome P 1A2 (CYP1A2) enzyme inhibitors, which may increase agomelatine’s plasma levels significantly. Agomelatine represents an interesting addition to the antidepressant market. en_US
dc.description.uri en_US
dc.identifier.citation Ouithoff, K 2012, 'Agomelatine : a review for general practitioners', South African Family Practice, vol. 54, no. 3, pp. 181-187. en_US
dc.identifier.issn 1026-9177 (print)
dc.identifier.issn 1726-426X (online)
dc.language.iso en en_US
dc.publisher South African Academy of Family Practice/Primary Care en_US
dc.rights © SAAFP en_US
dc.subject Family medicine en_US
dc.subject General practice en_US
dc.subject Primary care en_US
dc.subject Primary health care (PHC) en_US
dc.subject Education en_US
dc.subject.lcsh Antidepressants en
dc.title Agomelatine : a review for general practitioners en_US
dc.type Article en_US

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