Evaluation of four Cameroonian medicinal plants for anticancer, antigonorrheal and antireverse transcriptase activities

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dc.contributor.author Mbaveng, Armelle T.
dc.contributor.author Kuete, Victor
dc.contributor.author Mapunya, Manyatja Brenda
dc.contributor.author Beng, Veronique P.
dc.contributor.author Nkengfack, Augustin E.
dc.contributor.author Meyer, Jacobus Johannes Marion
dc.contributor.author Lall, Namrita
dc.date.accessioned 2012-07-05T06:40:10Z
dc.date.available 2012-07-05T06:40:10Z
dc.date.issued 2011-09
dc.description.abstract Methanol extracts from the leaves, bark and roots of four Cameroonian medicinal plants, Bersama engleriana, Cupressus lusitanica, Vitellaria paradoxa and Guibourtia tessmannii were tested for their in vitro cytotoxicity, antigonorrheal and antireverse transcriptase activities. The XTT (2,3-bis[2-methoxy-4-nitro-5-sulfophenyl]-2H-tetrazolium-5-carboxyanilide inner salt) assay, the dilution method and reverse transcriptase (RT) assay were used for the investigations. Preliminary phytochemical analysis of the extracts was also conducted using standard methods. Results showed that all extracts contained compounds belonging to the classes of phenols and terpenoids. They were also able to reduce in dose dependent manner, the proliferation of the cancer THP-1, DU145, HeLa, MCF-7, HepG2 and the normal Vero cells. IC50 values below 30 μg/ml were noted with extract from the three parts of B. engleriana on at least two of the five studied cancer cell lines, the lowest value of 5.9 μg/ml being obtained with sample from the bark. IC50 values below 30 μg/ml were also recorded with extracts from the leaves (on HeLa cells) and bark (on MCF-7) of G. tessmanii, and that from the bark of C. lusitanica on MCF-7. Extracts from B. engleriana and those from the bark of V. paradoxa gave the minimal inhibitory concentrations (MIC) values below 100 μg/ml on most of the 10 tested Nesseria gonorrhoeae strains. Extracts from B. engleriana also inhibited more than 80% the activity of the Human Immuno-deficiency Virus (HIV) enzyme. Finally, the results of the present study provide baseline information for the use of B. engleriana, C. lusitanica, G. tessmanii, V. paradoxa. en
dc.description.librarian nf2012 en
dc.description.uri http://www.elsevier.com/locate/etap en_US
dc.identifier.citation Armelle T. Mbaveng, Victor Kuete, Brenda M. Mapunya, Veronique P. Beng, Augustin E. Nkengfack, Jacobus J. Marion Meyer & Namrita Lall, Evaluation of four Cameroonian medicinal plants for anticancer, antigonorrheal and antireverse transcriptase activities, Environmental Toxicology and Pharmacology, vol. 32, no. 2, pp. 162-167 (2011), doi:10.1016/j.etap.2011.04.006. en
dc.identifier.issn 1382-6689 (print)
dc.identifier.issn 1872-7077 (online)
dc.identifier.other 10.1016/j.etap.2011.04.006
dc.identifier.uri http://hdl.handle.net/2263/19334
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.rights © 2011 Elsevier Ltd. All rights reserved. Notice : this is the author’s version of a work that was accepted for publication in Environmental Toxicology and Pharmacology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Environmental Toxicology and Pharmacology, vol. 32, no.2, 2011, doi.: 10.1016/j.etap.2011.04.006. en_US
dc.subject Anticancer agents en
dc.subject Anti-reverse transcriptase en
dc.subject Antigonorrheal transcriptase activities en
dc.subject.lcsh Antineoplastic agents -- Cameroon en
dc.subject.lcsh Medicinal plants -- Cameroon en
dc.subject.lcsh Plant extracts -- Therapeutic use en
dc.title Evaluation of four Cameroonian medicinal plants for anticancer, antigonorrheal and antireverse transcriptase activities en
dc.type Postprint Article en


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