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dc.contributor.author | Stegmann, George F.![]() |
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dc.contributor.author | Bester, Lynette![]() |
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dc.date.accessioned | 2012-07-02T08:06:12Z | |
dc.date.available | 2012-07-02T08:06:12Z | |
dc.date.issued | 2012-05-30 | |
dc.description.abstract | The ventilatory effects of intravenous midazolam (MDZ) were evaluated in isoflurane- anaesthetised goats. Eight female goats aged 2–3 years were fasted from food and water for 12 h. Anaesthesia was then induced using a face mask with isoflurane in oxygen, whilst the trachea was intubated with a cuffed tracheal tube and anaesthesia maintained with isoflurane at 1.5% end-tidal concentration. Ventilation was spontaneous. The goats were treated with either a saline placebo (PLC) or MDZ intravenously at 0.2 mg/kg. Analysis of variance for repeated measures was used for the analysis of data. Significance was taken at the 0.05 level. Differences between treatments were not statistically significant (p > 0.05) for tidal volume, ventilation rate, tidal volume/kg (VT/kg) and end-tidal carbon dioxide partial pressure. Within treatments, VT and VT/kg differed 5 min after MDZ administration; this was statistically significant (p < 0.05). The occurrence of apnoea in the MDZ-treated goats was statistically significant (p = 0.04) compared with the PLC treated goats. Intravenous MDZ at 0.2 mg/kg administered to isoflurane-anaesthetised goats may result in transient apnoea and a mild decrease in VT and VT/kg. | en |
dc.description.librarian | mn2012 | en |
dc.description.sponsorship | The University of Pretoria | en |
dc.description.uri | http://www.journals.co.za/ej/ejour_savet.html | en |
dc.identifier.citation | Stegmann GF, Bester L. Preliminary investigation into the ventilatory effects of midazolam in isofluraneanaesthetised goats. J S Afr Vet Assoc. 2012;83(1), Art. #9, 3 pages. http://dx.DOI.org/ 10.4102/jsava.v83i1.9 | en |
dc.identifier.issn | 0038-2809 | |
dc.identifier.issn | 10.4102/jsava.v83i1.9 | |
dc.identifier.uri | http://hdl.handle.net/2263/19280 | |
dc.language.iso | en | en |
dc.publisher | OpenJournals Publishing | en |
dc.rights | © 2012. The Authors. Licensee: AOSIS OpenJournals. This work is licensed under the Creative Commons Attribution License. | en |
dc.subject | Ventilatory effects | en |
dc.subject | Midazolam (MDZ) | en |
dc.subject | Isoflurane-anaesthetised goats | en |
dc.subject.lcsh | Veterinary medicine -- Research | en |
dc.subject.lcsh | Veterinary anesthesia | en |
dc.subject.lcsh | Goats -- Diseases | en |
dc.title | Preliminary investigation into the ventilatory effects of midazolam in isoflurane-anaesthetised goats | en |
dc.type | Article | en |