Biochemical and haematological changes in rats administered an aqueous extract of Prunus africana stem-bark at various dosage levels

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Authors

Gathumbi, P.K.
Mwangi, J.W.
Njiro, S.M.
Mugera, G.M.

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Volume Title

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Published by the Agricultural Research Council, Onderstepoort Veterinary Institute .

Abstract

An aqueous extract of Prunus africana (Hook. f.) Kalkm. (syn. Pygeum africanum) (Hook. f.) (Rosaceae) was administered daily at dosage rates of 10, 100 and 1000 mg/kg body mass to randomized groups of Sprague Dawley rats. The extract caused a moderate rise in plasma alanine aminotransferase and creatine kinase mainly at rates of 1000 mg/kg body mass, but it did not cause any significant variations in haematological parameters or in plasma levels of total proteins, albumin, aspartate aminotransferase, alkaline phosphatase and blood urea nitrogen at the dosage levels used. There were no overt clinical signs in any of the rats. It was concluded that the extract may contain components that are mildly toxic to the liver and heart of rats after repeated daily oral administrations of 1000 mg/kg body mass.

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The articles have been scanned in colour with a HP Scanjet 5590; 600dpi. Adobe Acrobat v.9 was used to OCR the text and also for the merging and conversion to the final presentation PDF-format.

Keywords

Veterinary medicine, Biochemical data, Haematological data, Prunus africana extract

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Citation

Gathumbi, PK, Mwangi, JW, Njiro, SM & Mugera, GM 2000, 'Biochemical and haematological changes in rats administered an aqueous extract of Prunus africana stem-bark at various dosage levels’. Onderstepoort Journal of Veterinary Research, vol. 67, no. 2, pp. 123-128.