Elevated plasma homocysteine concentrations are associated with an increased risk of cardiovascular disease. Nutritional supplementation of folic acid may be used to reduce homocysteine levels and thus minimise the risk of cardiovascular disease. This study examines 90 days of oral supplementation of a liquid supplement, containing folic acid and vitamin B12, on the plasma homocysteine levels in 20 sedentary adult men, aged 20-60 years. Supplier recommended dosage was administered daily. Blood was drawn pre- and post-test for measuring homocysteine, vitamin B12, and folate levels. Over the course of the study, the mean homocysteine levels of the active group decreased and folate levels increased significantly (p ≤ 0.05). The placebo group did not display these characteristics. The active supplement thus provided beneficial effects by decreasing disease risk. This was accomplished by a 15% reduction in homocysteine levels and increased plasma folate levels in the adult men.