Subendocardial fibrosis in left ventricular hypertrabeculation - cause or consequence?

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Authors

Ker, James A.
Du Toit-Prinsloo, Lorraine
Van Heerden, Willem Francois Petrus
Saayman, Gert

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Libertas Academica

Abstract

Left ventricular noncompaction has been classified as a primary cardiomyopathy with a genetic origin. This condition is morphologically characterized by a thickened, two-layered myocardium with numerous prominent trabeculations and deep, intertrabecular recesses. Recently, it has become clear that these pathological characteristics extend across a continuum with left ventricular hypertrabeculation at one end of the spectrum. The histological findings include areas of interstitial fibrosis. We present a case of left ventricular hypertrabeculation which presented as sudden infant death syndrome. Histologically areas of subendocardial fibrosis was prominent and we propose that this entity may be a hidden cause of arrhythmic death in some infants presenting as sudden infant death syndrome., with areas of subendocardial fibrosis as possible arrhythmogenic foci.

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Keywords

Sudden infant death syndrome, Hypertrabeculation, Noncompaction, Fibrosis

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Citation

Ker, J, Du Toit-Prinsloo, L, Van Heerden, WFP & Saayman, G 2011, 'Subendocardial fibrosis in left ventricular hypertrabeculation - cause or consequence?', Clinical Medicine Insights : Cardiology, vol. 5, pp. 13-16.