Subendocardial fibrosis in left ventricular hypertrabeculation - cause or consequence?
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Date
Authors
Ker, James A.
Du Toit-Prinsloo, Lorraine
Van Heerden, Willem Francois Petrus
Saayman, Gert
Journal Title
Journal ISSN
Volume Title
Publisher
Libertas Academica
Abstract
Left ventricular noncompaction has been classified as a primary cardiomyopathy with a genetic origin. This condition is
morphologically
characterized by a thickened, two-layered myocardium with numerous prominent trabeculations and deep, intertrabecular
recesses. Recently, it has become clear that these pathological characteristics extend across a continuum with left ventricular
hypertrabeculation at one end of the spectrum.
The histological findings include areas of interstitial fibrosis.
We present a case of left ventricular hypertrabeculation which presented as sudden infant death syndrome. Histologically areas of subendocardial
fibrosis was prominent and we propose that this entity may be a hidden cause of arrhythmic death in some infants presenting
as sudden infant death syndrome., with areas of subendocardial fibrosis as possible arrhythmogenic foci.
Description
Keywords
Sudden infant death syndrome, Hypertrabeculation, Noncompaction, Fibrosis
Sustainable Development Goals
Citation
Ker, J, Du Toit-Prinsloo, L, Van Heerden, WFP & Saayman, G 2011, 'Subendocardial fibrosis in left ventricular hypertrabeculation - cause or consequence?', Clinical Medicine Insights : Cardiology, vol. 5, pp. 13-16.