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Browsing Research Articles (Immunology) by UP Author "Steel, Helen C."
Now showing items 1-20 of 42
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Anderson, Ronald; Theron, Annette J.; Steel, Helen C.; Nel, Jan Gert; Tintinger, Gregory Ronald (MDPI Publishing, 2020-12)This study probed the di erential utilization of P2Y1 and P2Y12 receptors in mobilizing CD62P (P-selectin) from intracellular granules following activation of human platelets with adenosine 50-diphosphate (ADP, 100 mol L1) ...
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Anderson, Ronald; Theron, Annette J.; Steel, Helen C.; Durandt, Chrisna; Tintinger, Gregory Ronald; Feldman, Charles (Hindawi Publishing Corporation, 2014-03)The clinical relevance of the anti-inflammatory properties of beta-2 agonists remains contentious possibly due to differences in their molecular structures and agonist activities. The current study has compared the effects ...
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Cockeran, Riana; Dix-Peek, Therese; Dickens, Caroline; Steel, Helen C.; Anderson, Ronald; Feldman, Charles (Elsevier, 2020-02)OBJECTIVES : Exposure to cigarette smoke impacts on the virulence of Streptococcus pneumoniae (pneumococcus) by mechanisms including induction of biofilm formation. Most studies, however, have focused on individual strains ...
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Mkhize, Nomzamo; Kgokolo, Mahlatse C.M.; Steel, Helen C.; Meyer, Pieter W. A.; Kwofie, Luyanda Laura Illicia (Wiley, 2023-09)BACKGROUND : Psoriasis is an immune-mediated polygenic skin disorder. It is influenced by multiple genes as well as environmental factors including infection and trauma. Psoriasis is associated with molecular biomarkers ...
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Cockeran, Riana; Steel, Helen C.; Theron, Annette J.; Mitchell, Timothy J.; Feldman, Charles; Anderson, Ronald (Elsevier, 2011-11)The pneumolysin toxoid, Δ6 PLY, is a prototype pneumococcal protein vaccine candidate. However, its potentially detrimental residual pro-inflammatory interactions with human neutrophils are unknown. In the current study ...
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Matapa, Kgashane Given; Dix-Peek, Therese; Cockeran, Riana; Anderson, Ronald; Steel, Helen C.; Feldman, Charles (European Publishing, 2019-11)INTRODUCTION : Cigarette smoking is a well-recognized risk factor for development of severe, invasive pneumococcal disease. However, little is known about the direct effects of exposure to cigarette smoke on the virulence ...
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Malherbe, Glen Pierre; Steel, Helen C.; Cassol, Sharon; De Oliveira, Tulio; Seebregts, Christopher J.; Anderson, Ronald; Cassol, Edana; Rossouw, Theresa M. (Hindawi Publishing Corporation, 2014-04-06)Please read abstract in article.
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Anderson, Ronald; Steel, Helen C.; Cockeran, Riana; Smith, Anthony M.; Von Gottberg, Anne; De Gouveia, L.; Brink, Andries J.; Klugman, Keith P.; Mitchell, Timothy J.; Feldman, Charles (Oxford University Press, 2007-02)Please refer to abstract in article
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Cholo, Moloko C.; Steel, Helen C.; Fourie, P.B. (Petrus Bernardus); Germishuizen, Willem Andreas; Anderson, Ronald (Oxford University Press, 2012-02)Clofazimine, a lipophilic riminophenazine antibiotic, possesses both antimycobacterial and anti-inflammatory activities. However, its efficacy has been demonstrated only in the treatment of leprosy, not in human tuberculosis, ...
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Anderson, Ronald; Steel, Helen C.; Cockeran, Riana; Von Gottberg, Anne; De Gouveia, L.; Klugman, Keith P.; Mitchell, Timothy J.; Feldman, Charles (Oxford University Press, 2007-11)OBJECTIVES: To compare the effects of subinhibitory concentrations of amoxicillin, ceftriaxone, azithromycin, clarithromycin, erythromycin, telithromycin, clindamycin, ciprofloxacin, moxifloxacin, tobramycin and doxycycline ...
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Mellet, Juanita; Alessandrini, Marco; Steel, Helen C.; Pepper, Michael Sean (Nature Publishing Group, 2015-04)No abstract available
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Theron, Annette J.; Steel, Helen C.; Rapoport, Bernardo Leon; Anderson, Ronald (MDPI Publishing, 2020-11-20)Tumor cells are particularly adept at exploiting the immunosuppressive potential of neutrophils as a strategy to achieve uncontrolled proliferation and spread. Recruitment of neutrophils, particularly those of an immature ...
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Theron, Annette J.; Steel, Helen C.; Tintinger, Gregory Ronald; Gravett, Cornelia M.; Anderson, Ronald; Feldman, Charles (Hindawi Publishing Corporation, 2014)Cysteinyl leukotrienes (cysLTs) are produced predominantly by cells of the innate immune system, especially basophils, eosinophils, mast cells, and monocytes/macrophages. Notwithstanding potent bronchoconstrictor activity, ...
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Steel, Helen C.; Venter, Willem Daniel Francois; Theron, Annette J.; Anderson, Ronald; Feldman, Charles; Arulappan, Natasha; Rossouw, Theresa M. (MDPI, 2021-01-29)Systemic biomarkers of inflammation, including cytokines and chemokines, are potentially useful in the management of both HIV infection and non-AIDS-defining disorders. However, relatively little is known about the utility ...
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Madzime, Morris; Theron, Annette J.; Anderson, Ronald; Tintinger, Gregory; Steel, Helen C.; Meyer, Pieter Willem Adriaan; Nel, Jan Gert; Feldman, Charles; Rossouw, Theresa M. (Taylor and Francis, 2022)Please read abstract in the article.
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Cockeran, Riana; Steel, Helen C.; Wolter, Nicole; De Gouveia, L.; Von Gottberg, Anne; Klugman, Keith P.; Leanord, A.T.; Inverarity, D.J.; Mitchell, Timothy J.; Feldman, Charles; Anderson, Ronald (Scientific Research Publishing Inc, 2012-02)AIM: To investigate the effects of exposure of a macrolide-resistant [erm(B)-expressing] strain of Streptococcus pneumo- niae (strain 2507) to clarithromycin (0.5 and 5 mg/L) added at the outset and 6 hours after initiation ...
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Steel, Helen C.; Venter, Willem Daniel Francois; Theron, Annette J.; Anderson, Ronald; Feldman, Charles; Kwofie-Mensah, M.; Cronje, Tanita; Arullappan, Natasha; Rossouw, Theresa M. (Hindawi Publishing, 2018-12-09)Like HIV infection, smoking, which is common among HIV-infected persons, is associated with chronic, systemic inflammation. However, the possible augmentative effects of HIV infection and smoking and other types of tobacco ...
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Kgokolo, C.M.; Anderson, Katherine; Siwele, Shalate C.; Steel, Helen C.; Kwofie, Luyanda Laura Illicia; Sathekge, Mike Machaba; Meyer, Pieter Willem Adriaan; Rapoport, Bernardo Leon; Anderson, Ronald (Frontiers Media S.A., 2022-02-11)Xeroderma Pigmentosum (XP), an autosomal recessive disorder characterized by ultraviolet radiation-induced abnormalities of DNA excision and repair pathways is associated with early development of cutaneous cancers. ...
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Lipshitz, Melanie; Visser, J.; Anderson, Ronald; Nel, D.G.; Smit, T.G. (Theunis); Steel, Helen C.; Rapoport, Bernardo Leon (Springer, 2023-12)PURPOSE : Emerging biomarkers of cancer cachexia and their roles in sarcopenia and prognosis are poorly understood. Baseline assessments of anthropometrics, sarcopenia, cachexia status and biomarkers of cachexia were ...
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Kwofie, Luyanda Laura Illicia; Anderson, Ronald; Steel, Helen C.; Meyer, Pieter Willem Adriaan (Makerere University Medical School, 2021-06)BACKGROUND : Anti-human leukocyte antigen antibodies (anti-HLA) play a crucial role in graft. Detection of anti-HLA, both pre- and post-transplant is a crucial investigation in clinical organ transplantation. OBJECTIVES ...
Now showing items 1-20 of 42