Browsing Research Articles (Immunology) by UP Author "Myburgh, Renier"

Browsing Research Articles (Immunology) by UP Author "Myburgh, Renier"

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  • Cardiovascular pharmacogenetics 
    Myburgh, Renier; Hochfeld, Warren Ernst; Dodgen, Tyren Mark; Ker, James A.; Pepper, Michael Sean (Elsevier, 2012-03)
    Human genetic variation in the form of single nucleotide polymorphisms as well as more complex structural variations such as insertions, deletions and copy number variants, is partially responsible for the clinical ...
  • Lentivector knockdown of CCR5 in hematopoietic stem and progenitor cells confers functional and persistent HIV-1 resistance in humanized mice 
    Myburgh, Renier; Ivic, Sandra; Gers-Huber, Gustavo; Li, Duo; Audige, Annette; Rochat, Mary-Aude; Jaquet, Vincent; Regenass, Stephan; Manz, Markus G.; Pepper, Michael Sean; Salmon, Patrick; Krause, Karl-Heinz; Speck, Roberto F. (American Society for Microbiology, 2015-07)
    Gene-engineered CD34(+) hematopoietic stem and progenitor cells (HSPCs) can be used to generate an HIV-1-resistant immune system. However, a certain threshold of transduced HSPCs might be required for transplantation into ...
  • Optimization of critical hairpin features allows miRNA-based gene knockdown upon single-copy transduction 
    Myburgh, Renier; Cherpin, Ophélie; Schlaepfer, Erika; Rehrauer, Hubert; Speck, Roberto F.; Krause, Karl-Heinz; Salmon, Patrick (Nature Publishing Group, 2014)
    Gene knockdown using micro RNA (miRNA)-based vector constructs is likely to become a prominent gene therapy approach. It was the aim of this study to improve the efficiency of gene knockdown through optimizing the structure ...