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Browsing Research Articles (Immunology) by UP Author "Durandt, Chrisna"
Now showing items 1-16 of 16
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Anderson, Ronald; Theron, Annette J.; Steel, Helen C.; Durandt, Chrisna; Tintinger, Gregory Ronald; Feldman, Charles (Hindawi Publishing Corporation, 2014-03)The clinical relevance of the anti-inflammatory properties of beta-2 agonists remains contentious possibly due to differences in their molecular structures and agonist activities. The current study has compared the effects ...
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Anderson, Ronald; Theron, Annette J.; Nel, Jan Gert; Durandt, Chrisna; Cholo, Moloko C.; Feldman, Charles; Tintinger, Gregory Ronald (Frontiers Media, 2018-11-20)Although the inclusion of the cationic amphiphilic, anti-mycobacterial agent, clofazimine, in the chemotherapeutic regimens of patients with multidrug-resistant tuberculosis (TB) has contributed to improved outcomes, ...
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Dessels, Carla; Durandt, Chrisna; Pepper, Michael Sean (Taylor and Francis, 2019)Pooled human platelet lysate (pHPL) has been used to expand adipose-derived stromal cells (ASCs) and can be formulated using fresh or expired buffy coats (BCs) which are then resuspended in either plasma or an additive ...
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Grobbelaar, Simone; Mercier, Anne Elisabeth; Van den Bout, Iman; Durandt, Chrisna; Pepper, Michael Sean (Wiley, 2024-01)The generation of tissue from stem cells is an alluring concept as it holds a number of potential applications in clinical therapeutics and regenerative medicine. Mesenchymal stromal/stem cells (MSCs) can be isolated from ...
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Grobbelaar, Simone; Mercier, Anne Elisabeth; Van den Bout, Iman; Durandt, Chrisna; Pepper, Michael Sean (Wiley, 2024-01)The generation of tissue from stem cells is an alluring concept as it holds a number of potential applications in clinical therapeutics and regenerative medicine. Mesenchymal stromal/stem cells (MSCs) can be isolated from ...
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White, Marina; Feucht, Ute Dagmar; Duffley, Eleanor; Molokoane, Felicia; Durandt, Chrisna; Cassol, Edana; Rossouw, Theresa M.; Connor, Kristin L. (BMC, 2020-12-11)BACKGROUND : As mother-to-child transmission of HIV decreases, and the population of infants who are born HIV-exposed, but uninfected (HEU) continues to rise, there is a growing need to understand the development and health ...
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Durandt, Chrisna; Dessels, Carla; Da Silva, C.; Murdoch, Candice; Pepper, Michael Sean (Nature Publishing Group, 2019-11-04)Multipotent adipose-derived stromal/stem cells (ASCs) are candidates for use in cellular therapies for the treatment of a variety of conditions/diseases. Ex vivo expansion of freshly isolated ASCs may be necessary prior ...
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Wolmarans, Elize; Mellet, Juanita; Ambele, Melvin Anyasi; Durandt, Chrisna; Pepper, Michael Sean (Health and Medical Publishing Group, 2019-08)Cellular therapy has become a billion-dollar industry and is set to become one of the therapeutic pillars of healthcare in the 21st century. Adult stem cells, which include haematopoietic stem and progenitor cells (HSPCs) ...
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Durandt, Chrisna; Potgieter, J.C.; Mellet, Juanita; Herd, Candice Lee; Khoosal, R.; Nel, Jan Gert; Rossouw, Theresa M.; Pepper, Michael Sean (Health and Medical Publishing Group, 2019-09)Human immunodeficiency virus (HIV) infection not only leads to a compromised immune system, but also disrupts normal haematopoiesis, resulting in the frequent manifestation of cytopenias (anaemia, thrombocytopenia and ...
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Van Vollenstee, Fiona A.; Jackson, Carlo Stephan; Hoffmann, Danie; Potgieter, Marnie; Durandt, Chrisna; Pepper, Michael Sean (SpringerLink, 2016-10)Adipose derived mesenchymal stromal/stem cells (ASCs) are a heterogeneous population characterized by (a) their ability to adhere to plastic; (b) immunophenotypic expression of certain cell surface markers, while lacking ...
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Dodgen, Tyren Mark; Hochfeld, Warren Ernst; Fickl, Heidi; Asfaha, Sahle M.; Durandt, Chrisna; Rheeder, Paul; Drögemoller, Britt I.; Wright, Galen E.B.; Warnich, Louise; Labuschagne, Christiaan D.J.; Van Schalkwyk, Antoinette; Gaedigk, Andrea; Pepper, Michael Sean (BioMed Central, 2013-01-29)BACKGROUND: Adverse drug reactions and lack of therapeutic efficacy associated with currently prescribed pharmacotherapeutics may be attributed, in part, to inter-individual variability in drug metabolism. Studies on ...
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Durandt, Chrisna; Van Vollenstee, Fiona A.; Dessels, Carla; Kallmeyer, Karlien; De Villiers, Danielle; Murdoch, Candice; Potgieter, Marnie; Pepper, Michael Sean (American Society for Biochemistry and Molecular Biology, 2016-04)The ability of mesenchymal stromal cells (MSCs) to differentiate into adipocytes provides a cellular model of human origin to study adipogenesis in vitro. One of the major challenges in studying adipogenesis is the lack of ...
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De Villiers, Danielle; Potgieter, Marnie; Ambele, Melvin Anyasi; Adam, Ladislaus; Durandt, Chrisna; Pepper, Michael Sean (Springer, 2017-11)Interest in reactive oxygen species and adipocyte differentiation/adipose tissue function is steadily increasing. This is due in part to a search for alternative avenues for combating obesity, which results from the excess ...
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Wolmarans, Elize; Nel, Sulette; Durandt, Chrisna; Mellet, Juanita; Pepper, Michael Sean (Hindawi Publishing Corporation, 2018-12-06)There is still much to learn about the cells used for cell- and gene-based therapies in the clinical setting. Stem cells are found in virtually all tissues in the human body. As a result, cells isolated from these tissues ...
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Du Plessis, Lizette; Bonato, M.; Durandt, Chrisna; Cloete, S.W.P.; Soley, John Thomson (CSIRO Publishing, 2019)Sperm macrocephaly syndrome (SMS) is characterised by a high percentage of spermatozoa with enlarged heads and multiple tails, and is related to infertility. Although this multiple sperm defect has been described in other ...
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Jackson, Carlo Stephan; Durandt, Chrisna; Janse van Rensburg, IIse; Praloran, Vincent; De la Grange, Philippe Brunet; Pepper, Michael Sean (Elsevier, 2017-05)Culture conditions used for the expansion of hematopoietic stemand progenitor cells (HSCs andHPCs, collectively HSPCs) should ideally favor the self renewal of long-termHSCs. At 20% O2, the synthesis of HIF-1α is balanced by ...
Now showing items 1-16 of 16