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Browsing Research Articles (Immunology) by UP Author "Alessandrini, Marco"
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Kappala, S.S.; Alessandrini, Marco; Matlhako, T.; Beltchev, E.; Pool, Roger; Pepper, Michael Sean
(Hindawi Publishing Corporation, 2017-11-07)
Acute myeloid leukemia (AML) is characterized by proliferation of the myeloid lineage and accumulation of immature
hematopoietic cells in the bone marrow and is typified by marked heterogeneity both in response to treatment ...
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Mellet, Juanita; Alessandrini, Marco; Steel, Helen C.; Pepper, Michael Sean
(Nature Publishing Group, 2015-04)
No abstract available
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Van Rensburg, J.; Alessandrini, Marco; Stewart, Cheryl; Pepper, Michael Sean
(Health and Medical Publishing Group, 2018-08)
Cystic fibrosis (CF), one of the most commonly observed and diagnosed fatal monogenic disorders globally, was initially thought to affect
individuals of Caucasian/European descent almost exclusively. It is increasingly ...
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Dodgen, Tyren Mark; Drögemöller, Britt I.; Wright, Galen E.B.; Warnich, Louise; Steffens, Francois E.; Cromarty, Allan Duncan; Alessandrini, Marco; Pepper, Michael Sean
(Future Medicine, 2015-08)
AIM : To align predicted and measured CYP2C19 phenotype in a South African cohort.
MATERIALS AND METHODS : Genotyping of CYP2C19*2, *3, *9, *15, *17, *27 and *28 was
performed using PCR-RFLP, and an Activity Score (AS) ...
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Dessels, Carla; Alessandrini, Marco; Pepper, Michael Sean
(Wiley Open Access, 2018-09)
Hematopoietic stem cell transplantation (HSCT) is common practice today for life threatening
malignant and non-malignant diseases of the blood and immune systems. Umbilical cord blood
(UCB) is rich in hematopoietic stem ...
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Chaudhry, Mamoonah; Alessandrini, Marco; Rademan, Jacobus; Dodgen, Tyren Mark; Steffens, Francois E.; Van Zyl, Danie G.; Gaedigk, Andrea; Pepper, Michael Sean
(Future Medicine, 2017-03)
AIM : Therapy with low-dose amitriptyline is commonly used to treat painful diabetic peripheral neuropathy. There is a knowledge gap, however, regarding the role of variable CYP2D6-mediated drug metabolism and side effects ...
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Botes, W.M.; Alessandrini, Marco
(Health and Medical Publishing Group, 2015-08)
The promise stem cell therapy holds for curing diseases for which no therapy currently exists is often translated as fact. Unfortunately, enforced misconceptions between fact and promise often also translate into exploitation ...
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Čolić, Antoinette; Alessandrini, Marco; Pepper, Michael Sean
(Informa Healthcare, 2015-05)
The CYP450 and UGT enzymes are involved in phase I and phase II metabolism of the majority of clinically prescribed drugs, including the
non-nucleoside reverse transcriptase inhibitors, efavirenz and nevirapine, used in ...
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Alessandrini, Marco; Chaudhry, Mamoonah; Dodgen, Tyren Mark; Pepper, Michael Sean
(Mary Ann Liebert, 2016-10)
In a move indicative of the enthusiastic support of precision medicine, the U.S. President Barack Obama announced the Precision Medicine Initiative in January 2015. The global precision medicine ecosystem is, thus, receiving ...
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Chaudhry, Mamoonah; Alessandrini, Marco; Pepper, Michael Sean
(Elsevier, 2016-06)
The rate of mortality in developing countries due to communicable
disease remains alarmingly high. The leading contributors to disease
burden in these regions are the so-called “big three”, namely HIV/
AIDS, TB, and ...
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Alessandrini, Marco; Pepper, Michael Sean
(Future Medicine, 2014-02)
Countries in Africa have a high burden of communicable disease, and are experiencing an increase in non-communicable diseases due to the effects of globalization, industrialization and urbanization. The costs incurred ...
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Alessandrini, Marco; Klose, Kristin; Pepper, Michael Sean
(eContent Management Pty Ltd., 2013-06)
Although formalised practices of technology transfer at research institutions are well established in many developed countries, these practices are still very much in their infancy in South Africa. The country is however ...