Browsing Research Articles (Immunology) by Title

Browsing Research Articles (Immunology) by Title

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  • Haematopoietic stem cell transplantation in South Africa : current limitations and future perspectives 
    Grobbelaar, Simone; Mercier, Anne Elisabeth; Verburgh, Estelle; Brittain, David; Pepper, Michael Sean (Health and Medical Publishing Group, 2019-08)
    The growing need for haematopoietic stem cell transplantation (HSCT) is reflected in the increasing number of transplants performed globally each year. HSCT provides life-changing and potentially curative therapy for a ...
  • Harmful interactions of non-essential heavy metals with cells of the innate immune system 
    Theron, Annette J.; Tintinger, Gregory Ronald; Anderson, Ronald (2012-04-16)
    In trace amounts, some heavy metals are essential for optimum health, while exposure to others, which are non-essential, presents the potential hazard of acute or chronic organ toxicity. Cadmium, mercury, lead, ...
  • HBV/HIV co-infection : the dynamics of HBV in South African patients with AIDS 
    Mayaphi, Simnikiwe Horatious; Rossouw, Theresa M.; Masemola, Difuro P.; Olorunju, Steve A.S.; Mphahlele, M. Jeffrey; Martin, Desmond J. (Health and Medical Publishing Group, 2012-03)
    OBJECTIVE: As sub-Saharan Africa is highly endemic for hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infections, and their co-infection requires special management, we aimed to assess the serological and ...
  • Helicobacter pylori and gastric cancer 
    Fritz, Elongo Lekunze; Van der Merwe, Schalk Willem (Health and Medical Publishing Group, 2009-05)
    Gastric cancer is one of the most common forms of cancer worldwide, with an estimated 930 000 new cases diagnosed each year. It is thought to be more prevalent in men than in women. In South Africa the latest cancer ...
  • Hemangiomas - current therapeutic strategies 
    Mabeta, Peaceful Lucy; Pepper, Michael Sean (UBC Press, 2011-07)
    Hemangiomas are benign neoplasms of the vasculature frequently encountered in children. Several studies have shown that these tumors are characterized by excessive angiogenesis. Although benign, the lesions can present ...
  • Heterogeneity of cell therapy products 
    Wolmarans, Elize; Mellet, Juanita; Ambele, Melvin Anyasi; Durandt, Chrisna; Pepper, Michael Sean (Health and Medical Publishing Group, 2019-08)
    Cellular therapy has become a billion-dollar industry and is set to become one of the therapeutic pillars of healthcare in the 21st century. Adult stem cells, which include haematopoietic stem and progenitor cells (HSPCs) ...
  • Heterozygosity of p16 expression in an oral squamous cell carcinoma with associated loss of heterozygosity and copy number alterations 
    Ambele, Melvin Anyasi; Pepper, Michael Sean; Van Heerden, Marlene B.; Van Heerden, Willem Francois Petrus (Wiley, 2019-05)
    BACKGROUND : Oral field cancerization describes a multifocal development process involving many cells at once in response to prolong exposure to carcinogens. This case demonstrated differential p16 expression in different ...
  • High mobility group box 1 in human cancer 
    Rapoport, Bernardo Leon; Steel, Helen C.; Theron, Annette J.; Heyman, Liezl; Smit, Teresa; Ramdas, Yastira; Anderson, Ronald (MDPI, 2020-07)
    High mobility group box 1 (HMGB1) is an extremely versatile protein that is located predominantly in the nucleus of quiescent eukaryotic cells, where it is critically involved in maintaining genomic structure and function. ...
  • Histopathology and genotyping in infectious spondylitis of HIV- and HIV+ patients 
    Danaviah, S.; Govender, S.; Cassol, Sharon (Lippincott Williams and Wilkins, 2007-07)
    Approximately 2 million South Africans are HIV/TB coinfected, and many develop skeletal disease. The resurgence of spinal tuberculosis, including atypical forms, is due largely to HIV-associated immune suppression. We ...
  • HIV and haematopoiesis 
    Durandt, Chrisna; Potgieter, J.C.; Mellet, Juanita; Herd, Candice Lee; Khoosal, R.; Nel, Jan Gert; Rossouw, Theresa M.; Pepper, Michael Sean (Health and Medical Publishing Group, 2019-09)
    Human immunodeficiency virus (HIV) infection not only leads to a compromised immune system, but also disrupts normal haematopoiesis, resulting in the frequent manifestation of cytopenias (anaemia, thrombocytopenia and ...
  • HIV as a cause of immune activation and immunosenescence 
    Sokoya, T.; Steel, Helen C.; Nieuwoudt, M.; Rossouw, Theresa M. (Hindawi Publishing, 2017)
    Systemic immune activation has emerged as an essential component of the immunopathogenesis of HIV. It not only leads to faster disease progression, but also to accelerated decline of overall immune competence. HIV-associated ...
  • HIV drug resistance levels in adults failing first-line antiretroviral therapy in an urban and a rural setting in South Africa 
    Rossouw, Theresa M.; Nieuwoudt, Martin; Manasa, Justen; Malherbe, Glen Pierre; Lessells, Richard J.; Pillay, Sureshnee; Danaviah, Siva; Mahasha, Phetole; Van Dyk, Gisela; De Oliveira, Tulio (Wiley, 2017-02)
    OBJECTIVES : Urban and rural HIV treatment programmes face different challenges in the long-term management of patients. There are few studies comparing drug resistance profiles in patients accessing treatment through these ...
  • HIV management in practice : South Africa has the largest HIV epidemic in the world and it is therefore imperative that all health 
    Rossouw, Theresa M. (Health and Medical Publishing Group, 2011-05)
    This article briefly reviews the new South African HIV treatment guidelines for adults and adolescents, children and pregnant women. It focuses on the timing of the initiation of antiretroviral treatment and argues for ...
  • HIV-associated bacterial pneumonia 
    Feldman, Charles; Anderson, Ronald (Elsevier, 2013-06)
    NiO/activated carbon (AC) composites were successfully synthesized via a hydrothermal reflux process as an electrode material for carbon monoxide (CO) gas sensor application. The X-ray diffraction (XRD) analysis was used ...
  • HLA typing : conventional techniques v. next-generation sequencing 
    Mellet, Juanita; Gray, C.M.; Pepper, Michael Sean (Health and Medical Publishing Group, 2016-01)
    BACKGROUND. The large number of population-specific polymorphisms present in the HLA complex in the South African (SA) population reduces the probability of finding an adequate HLA-matched donor for individuals in need ...
  • HLA-DRB1 shared epitope genotyping using the revised classification and its association with circulating autoantibodies, acute phase reactants, cytokines and clinical indices of disease activity in a cohort of South African rheumatoid arthritis patients 
    Meyer, Pieter Willem Adriaan; Hodkinson, Bridget; Ally, Mahmood Moosa Tar Mahomed; Musenge, Eustasius; Wadee, Ahmed; Fickl, Heidi; Tikly, Mohammed; Anderson, Ronald (2011-10-06)
    INTRODUCTION: The revised shared epitope (SE) concept in rheumatoid arthritis (RA) is based on the presence (S) or absence (X) of the SE RAA amino acid motif at positions 72 to 74 of the third hypervariable region of the ...
  • Homing properties of mesenchymal stromal cells 
    Kallmeyer, Karlien; Pepper, Michael Sean (Taylor and Francis, 2015-04)
    A large number of clinical trials are underway to assess the therapeutic potential of mesenchymal stromal cells. This is based on preclinical observations that point to the probable efficacy of these cells. Very little ...
  • How nuclear envelope dynamics can direct laminopathy phenotypes 
    Van Heerden, David; Klima, Stefanie; Van den Bout, Iman (Elsevier, 2024-02)
    The nuclear envelope separates the genome from the cytoplasmic environment. However, the nuclear envelope is also physically associated with the genome and exerts influence on gene expression and genome modification. The ...
  • Human adipose derived mesenchymal stromal cells transduced with GFP lentiviral vectors : assessment of immunophenotype and differentiation capacity in vitro 
    Van Vollenstee, Fiona A.; Jackson, Carlo Stephan; Hoffmann, Danie; Potgieter, Marnie; Durandt, Chrisna; Pepper, Michael Sean (SpringerLink, 2016-10)
    Adipose derived mesenchymal stromal/stem cells (ASCs) are a heterogeneous population characterized by (a) their ability to adhere to plastic; (b) immunophenotypic expression of certain cell surface markers, while lacking ...
  • The human genome and molecular medicine – promises and pitfalls 
    Pepper, Michael Sean (Health and Medical Publishing Group, 2010-11)
    No abstract available.