Browsing Research Articles (Genetics) by Type "Article"

Browsing Research Articles (Genetics) by Type "Article"

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  • Arable agriculture changes soil microbial communities in the South African Grassland Biome 
    Nkuekam, Gilbert Kamgan; Cowan, Don A.; Valverde, Angel (AOSIS Open Journals, 2018-05-30)
    Many studies, mostly in temperate regions of the northern hemisphere, have demonstrated that agricultural practices affect the composition and diversity of soil microbial communities. However, very little is known about ...
  • Architecture and distribution of introns in core genes of four Fusarium species 
    Phasha, Mmatshepho Malekgale; Wingfield, Brenda D.; Coetzee, Martin Petrus Albertus; Santana, Quentin C.; Fourie, Gerda; Steenkamp, Emma Theodora (Genetics Society of America, 2017-11)
    Removal of introns from transcribed RNA represents a crucial step during the production of mRNA in eukaryotes. Available whole-genome sequences and expressed sequence tags (ESTs) have increased our knowledge of this ...
  • Armillaria root rot threatens Cameroon’s Penja pepper (Piper nigrum L.) 
    Tigang, Sandrine Petchayo; Tchotet Tchoumi, James Michel; Roux, Jolanda; Nguefack, Julienne; Begoude Boyogueno, Aime Didier; Mbenoun, Michael; Mfegue, Crescence Virginie; Nyasse, Salomon; Nkeng, Michel Ndoumbe; Ten Hoopen, Gerben Martijn (Sociedade Brasileira de Fitopatologia, 2020-10)
    Penja pepper (Piper nigrum) produced in Cameroon has long been recognized for its exceptional organoleptic quality. The pepper vine is grown using a support tree (Spondias mombin) in Cameroon. A root disease is associated ...
  • Armillaria root-rot pathogens : species boundaries and global distribution 
    Coetzee, Martin Petrus Albertus; Wingfield, Brenda D.; Wingfield, Michael J. (MDPI, 2018-10-24)
    This review considers current knowledge surrounding species boundaries of the Armillaria root-rot pathogens and their distribution. In addition, a phylogenetic tree using translation elongation factor subunit 1-alpha ...
  • The artemiside-artemisox-artemisone-m1 tetrad : efficacies against blood stage p. falciparum parasites, dmpk properties, and the case for artemiside 
    Gibhard, Liezl; Coertzen, Dina; Reader, Janette; Van der Watt, Mariette Elizabeth; Birkholtz, Lyn-Marie; Wong, Ho Ning; Batty, Kevin T.; Haynes, Richard K.; Wiesner, Lubbe (MDPI, 2021-12-03)
    Because of the need to replace the current clinical artemisinins in artemisinin combination therapies, we are evaluating fitness of amino-artemisinins for this purpose. These include the thiomorpholine derivative artemiside ...
  • Assembling metagenomes, one community at a time 
    Van der Walt, Andries Johannes; Van Goethem, Marc W.; Ramond, Jean-Baptiste; Makhalanyane, Thulani P.; Reva, Oleg N.; Cowan, Don A. (BioMed Central, 2017-07-10)
    BACKGROUND : Metagenomics allows unprecedented access to uncultured environmental microorganisms. The analysis of metagenomic sequences facilitates gene prediction and annotation, and enables the assembly of draft genomes, ...
  • Assembly of complete genome sequences of negative-control and experimental strain variants of staphylococcus aureus ATCC BAA-39 selected under the effect of the drug FS-1, which induces antibiotic resistance reversion 
    Joubert, Monique; Reva, Oleg N.; Korotetskiy, Ilya S.; Shvidko, Sergey V.; Shilov, Sergey V.; Jumagaziyeva, Ardak B.; Kenesheva, Sabina T.; Suldina, Natalya A.; Ilin, Aleksandr I. (American Society for Microbiology, 2019-07)
    Staphylococcus aureus ATCC BAA-39 is the reference organism for a multidrug-resistant Staphylococcus aureus (MRSA) strain that was used to study druginduced resistance reversion by an iodine-containing nanomolecular ...
  • Assessing associations between the AURKAHMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers 
    Blanco, Ignacio; Kuchenbaecker, Karoline; Cuadras, Daniel; Wang, Xianshu; Barrowdale, Daniel; De Garibay, Gorka Ruiz; Librado, Pablo; Sanchez-Gracia, Alejandro; Rozas, Julio; Bonifaci, Nuria; McGuffog, Lesley; Pankratz, Vernon S.; Islam, Abul; Mateo, Francesca; Berenguer, Antoni; Petit, Anna; Catala, Isabel; Brunet, Joan; Feliubadalo, Lidia; Tornero, Eva; Benitez, Javier; Osorio, Ana; Cajal, Teresa Ramony; Nevanlinna, Heli; Aittomaki, Kristiina; Arun, Banu K.; Toland, Amanda Ewart; Karlan, Beth Y.; Walsh, Christine; Lester, Jenny; Greene, Mark H.; Mai, Phuong L.; Nussbaum, Robert L.; Andrulis, Irene L.; Domchek, Susan M.; Nathanson, Katherine L.; Rebbeck, Timothy R.; Barkardottir, Rosa B.; Jakubowska, Anna; Lubinski, Jan; Durda, Katarzyna; Jaworska-Bieniek, Katarzyna; Claes, Kathleen; Van Maerken, T.; Diez, Orland; Hansen, Thomas V.O.; Jonson, Lars; Gerdes, Anne-Marie; Ejlertsen, Bent; De la Hoya, Miguel; Caldes, Trinidad; Dunning, Alison M.; Oliver, Clare; Fineberg, Elena; Cook, Margaret; Peock, Susan; McCann, Emma; Murray, Alex; Jacobs, Chris; Pichert, Gabriella; Lalloo, Fiona; Chu, Carol; Dorkins, Huw; Paterson, Joan; Ong, Kai-Ren; Teixeira, Manuel R.; Teixeira; Hogervorst, Frans B.L.; Van der Hout, Annemarie H.; Seynaeve, Caroline; Van der Luijt, Rob B.; Ligtenberg, Marjolijn J.L.; Devilee, Peter; Wijnen, Juul T.; Rookus, Matti A.; Meijers-Heijboer, Hanne E.J.; Blok, Marinus J.; Van den Ouweland, Ans M.W.; Aalfs, Cora M.; Rodriguez, Gustavo C.; Phillips, Kelly-Anne A.; Piedmonte, Marion; Nerenstone, Stacy R.; Bae-Jump, Victoria L.; O'Malley, David M.; Ratner, Elena S.; Schmutzler, Rita K.; Wappenschmidt, Barbara; Rhiem, Kerstin; Engel, Christoph; Meindl, Alfons; Ditsch, Nina; Arnold, Norbert; Plendl, Hansjoerg; Niederacher, Dieter; Sutter, Christian; Wang-Gohrke, Shan; Steinemann, Doris; Preisler-Adams, Sabine; Kast, Karin; Varon-Mateeva, Raymonda; Gehrig, Andrea; Bojesen, Anders; Pedersen, Inge Sokilde; Sunde, Lone; Jensen, Uffe Birk; Thomassen, Mads; Kruse, Torben A.; Foretova, Lenka; Peterlongo, Paolo; Bernard, Loris; Peissel, Bernard; Scuvera, Giulietta; Manoukian, Siranoush; Radice, Paolo; Ottini, Laura; Montagna, Marco; Agata, Simona; Maugard, Christine; Simard, Jacques; Soucy, Penny; Berger, Andreas; Fink-Retter, Anneliese; Singer, Christian F.; Rappaport, Christine; Geschwantler-Kaulich, Daphne; Tea, Muy-Kheng; Pfeiler, Georg; BCFR (Breast Cancer Family Registry); John, Esther M.; Miron, Alexander; Neuhausen, Susan L.; Terry, Mary Beth; Chung, Wendy K.; Daly, Mary B.; Goldgar, David E.; Janavicius, Ramunas; Dorfling, Cecilia Maria; Jansen van Rensburg, Elizabeth; Fostira, Florentia; Konstantopoulou, Irene; Garber, Judy; Godwin, Andrew K.; Olah, Edith; Narod, Steven A.; Rennert, Gad; Paluch, Shani Shimon; Laitman, Yael; Friedman, Eitan; SWE-BRCA; Liljegren, Annelie; Rantala, Johanna; Stenmark-Askmalm, Marie; Loman, Niklas; Imyanitov, Evgeny N.; Hamann, Ute; Investigators, kConFab; Spurdle, Amanda B.; Healey, Sue; Weitzel, Jeffrey N.; Herzog, Josef; Margileth, David; Gorrini, Chiara; Esteller, Manel; Gomez, Antonio; Sayols, Sergi; Vidal, Enrique; Heyn, Holger; GEMO; Stoppa-Lyonnet, Dominique; Leone, Melanie; Barjhoux, Laure; Fassy-Colcombet, Marion; De Pauw, Antoine; Lasset, Christine; Ferrer, Sandra Fert; Castera, Laurent; Berthet, Pascaline; Cornelis, Francois; Bignon, Yves-Jean; Damiola, Francesca; Mazoyer, Sylvie; Sinilnikova, Olga M.; Maxwell, Christopher A.; Vijai, Joseph; Robson, Mark; Kauff, Noah; Corines, Marina J.; Villano, Danylko; Cunningham, Julie M.; Lee, Adam; Lindor, Noralane; Lázaro, Conxi; Easton, Douglas F.; Offit, Kenneth; Chenevix-Trench, Georgia; Couch, Fergus J.; Antoniou, Antonis C.; Pujana, Miguel Angel (Public Library of Science, 2015-04-01)
    While interplay between BRCA1 and AURKA-RHAMM-TPX2-TUBG1 regulates mammary epithelial polarization, common genetic variation in HMMR (gene product RHAMM) may be associated with risk of breast cancer in BRCA1 mutation ...
  • Bacterial vaginosis : current diagnostic avenues and future opportunities 
    Redelinghuys, Mathys J.; Geldenhuys, Janri; Jung, Hyun-Sul; Kock, Marleen M. (Frontiers Media, 2020-08-11)
    A healthy female genital tract harbors a microbiome dominated by lactic acid and hydrogen peroxide producing bacteria, which provide protection against infections by maintaining a low pH. Changes in the bacterial ...
  • Bark beetle mycobiome : collaboratively defined research priorities on a widespread insect-fungus symbiosis 
    Hulcr, Jiri; Barnes, Irene; De Beer, Z. Wilhelm; Duong, Tuan A.; Gazis, Romina; Johnson, Andrew J.; Jusino, Michelle A.; Kasson, Matthew T.; Li, You; Lynch, Shannon; Mayers, Chase; Musvuugwa, Tendai; Roets, Francois; Seltmann, Katja C.; Six, Diana; Vanderpool, Dan; Villari, Caterina (Springer, 2020-06-03)
    One of the main threats to forests in the Anthropocene are novel or altered interactions among trees, insects and fungi. To critically assess the contemporary research on bark beetles, their associated fungi, and their ...
  • The bark-beetle-associated fungus, endoconidiophora polonica, utilizes the phenolic defense compounds of its host as a carbon source 
    Wadke, Namita; Kandasamy, Dineshkumar; Vogel, Heiko; Lah, Ljerka; Wingfield, Brenda D.; Paetz, Christian; Wright, Louwrance Peter; Gershenzon, Jonathan; Hammerbacher, Almuth (American Society of Plant Biologists, 2016-06)
    Norway spruce (Picea abies) is periodically attacked by the bark beetle Ips typographus and its fungal associate, Endoconidiophora polonica, whose infection is thought to be required for successful beetle attack. Norway ...
  • Basal metabolic rate scaled to body mass between species by the fractal dimension of the vascular system and body composition 
    Roux, Carl Z. (South African Society for Animal Science, 2017)
    Exercise-induced maximum aerobic metabolic rate (MMR) is related to the fractal dimension (D) of the self-similar vascular blood transport system by a whole body mass (Mw) power with exponent b of the form b = D/3. The ...
  • Benefits of maize resistance breeding and chemical control against northern leaf blight in smallholder farms in South Africa 
    Berger, David Kenneth; Mokgobu, Tumisang; De Ridder, Katrien; Christie, Nanette; Aveling, T.A.S. (Terry) (AOSIS Open Journals, 2020-11-26)
    Maize underpins food security in South Africa. An annual production of more than 10 million tons is a combination of the output of large-scale commercial farms plus an estimated 250 000 ha cultivated by smallholder ...
  • The benefits of whole genome sequencing for foodborne outbreak investigation from the perspective of a National Reference laboratory in a smaller country 
    Nouws, Stephanie; Bogaerts, Bert; Verhaegen, Bavo; Denayer, Sarah; Crombe, Florence; De Rauw, Klara; Pierard, Denis; Marchal, Kathleen; Vanneste, Kevin; Roosens, Nancy H.C.; De Keersmaecker, Sigrid C.J. (MDPI, 2020-08-01)
    Gradually, conventional methods for foodborne pathogen typing are replaced by whole genome sequencing (WGS). Despite studies describing the overall benefits, National Reference Laboratories of smaller countries often ...
  • Benzimidazole derivatives are potent against multiple life cycle stages of Plasmodium falciparum malaria parasites 
    Leshabane, Meta Kgaogelo; Dziwornu, Godwin Akpeko; Coertzen, Dina; Reader, Janette; Moyo, Phanankosi; Van der Watt, Mariette Elizabeth; Chisanga, Kelly; Nsanzubuhoro, Consolata; Ferger, Richard; Erlank, Erica; Venter, Nelius; Koekemoer, Lizette; Chibale, Kelly; Birkholtz, Lyn-Marie (American Chemical Society, 2021-03)
    The continued emergence of resistance to front-line antimalarial treatments is of great concern. Therefore, new compounds that potentially have a novel target in various developmental stages of Plasmodium parasites are ...
  • Bioassay-guided isolation and identification of gametocytocidal compounds from Artemisia afra (Asteraceae) 
    Moyo, Phanankosi; Kunyane, Phaladi; Selepe, Mamoalosi A.; Eloff, Jacobus Nicolaas; Niemand, Jandeli; Louw, Abraham Izak; Maharaj, Vinesh J.; Birkholtz, Lyn-Marie (BioMed Central, 2019-03-08)
    BACKGROUND : Optimal adoption of the malaria transmission-blocking strategy is currently limited by lack of safe and efficacious drugs. This has sparked the exploration of different sources of drugs in search of ...
  • Biodiversity : so much more than legs and leaves 
    Cowan, Don A.; Rybicki, Edward P.; Tuffin, Marla I.; Valverde, Angel; Wingfield, Michael J. (AOSIS Open Journals, 2013-11)
    Microorganisms inhabit virtually every possible niche on Earth, including those at the outer envelope of survival. However, the focus of most conservation authorities and ecologists is the ‘legs and leaves’ side of biology ...
  • Biodiversity of Lecanosticta pine-needle blight pathogens suggests a Mesoamerican Centre of origin 
    Van der Nest, Ariska; Wingfield, Michael J.; Ortiz, Paulo C.; Barnes, Irene (International Mycological Association, 2019-06-07)
    Lecanosticta acicola causes the disease known as brown spot needle blight (BSNB), on Pinus species. The pathogen is thought to have a Central American centre of origin. This was based on the morphological variation between ...
  • A bioeconomic model for the optimization of local canine rabies control 
    Anderson, Aaron; Kotze, Johann; Shwiff, Stephanie A; Hatch, Brody; Slootmaker, Chris; Conan, Anne; Knobel, Darryn Leslie; Nel, Louis Hendrik (Public Library of Science, 2019-05-22)
    We present a new modeling tool that can be used to maximize the impact of canine rabies management resources that are available at the local level. The model is accessible through a web-based interface that allows for ...
  • Biology of a putative male aggregation-sex pheromone in Sirex noctilio (Hymenoptera: Siricidae) 
    Guignard, Quentin; Bouwer, Marc Clement; Slippers, Bernard; Allison, Jeremy D. (Public Library of Science, 2020-12-31)
    A putative male-produced pheromone has recently been described for the global pest of pines, Sirex noctilio, but field-activity has not been demonstrated. This study aimed to investigate the pheromone biology of S. ...