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Browsing Genetics by Subject "Target identification"

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Human Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases

Morahan, Belinda J.; Abrie, Clarissa; Al-Hasani, Keith; Batty, Mitchell B.; Corey, Victoria; Cowell, Anne N.; Niemand, Jandeli; Winzeler, Elizabeth A.; Birkholtz, Lyn-Marie; Doerig, Christian; Garcia-Bustos, Jose F. (Nature Research, 2020-11)

Mitosis has been validated by numerous anti-cancer drugs as being a druggable process, and selective inhibition of parasite proliferation provides an obvious opportunity for therapeutic intervention against malaria. ...

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