Browsing Genetics by Subject "Natural products"

Browsing Genetics by Subject "Natural products"

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  • Anticancer agents from diverse natural sources 
    Khazir, Jabeena; Mir, Bilal Ahmad; Pilcher, Lynne A.; Riley, Darren L.; Cowan, Don A. (Natural Product, 2014-11)
    Cancer is one of the major causes of death and the number of new cases, as well as the number of individuals living with cancer, is expanding continuously. Worldwide the alarming rise in mortality rate due to cancer has ...
  • Bioassay-guided isolation and identification of gametocytocidal compounds from Artemisia afra (Asteraceae) 
    Moyo, Phanankosi; Kunyane, Phaladi; Selepe, Mamoalosi A.; Eloff, Jacobus Nicolaas; Niemand, Jandeli; Louw, Abraham Izak; Maharaj, Vinesh J.; Birkholtz, Lyn-Marie (BioMed Central, 2019-03-08)
    BACKGROUND : Optimal adoption of the malaria transmission-blocking strategy is currently limited by lack of safe and efficacious drugs. This has sparked the exploration of different sources of drugs in search of ...
  • Natural products : a potential source of malaria transmission blocking drugs? 
    Moyo, Phanankosi; Mugumbate, Grace; Eloff, Jacobus Nicolaas; Louw, Abraham Izak; Maharaj, Vinesh J.; Birkholtz, Lyn-Marie (MDPI Publishing, 2020-09-17)
    The ability to block human-to-mosquito and mosquito-to-human transmission of Plasmodium parasites is fundamental to accomplish the ambitious goal of malaria elimination. The WHO currently recommends only primaquine as a ...
  • Natural products as lead compounds in drug discovery 
    Khazir, Jabeena; Cowan, Don A.; Mir, Bilal Ahmad (Taylor and Francis, 2013-05)
    This review surveys the diversity of natural products (NPs) derived from terrestrial plants, micro-organisms, marine organisms and fungi used in the treatment of various diseases. A wide spectrum of compounds derived ...
  • A novel cardenolide glycoside isolated from Xysmalobium undulatum reduces levels of the Alzheimer’s disease-associated β-amyloid peptides aβ42 in vitro 
    Thakur, Anuradha; Moyo, Phanankosi; Van der Westhuizen, Carl Johan; Yang, Hyun Ok; Maharaj, Vinesh J. (MDPI, 2021-07)
    Elevated levels of the amylo β-proteins (Aβ), particularly Aβ42, are associated with a high risk of Alzheimer’s disease (AD). The Aβ proteins are produced from cellular processing of the amyloid precursor proteins (APPs). ...
  • Role of plants in anticancer drug discovery 
    Khazir, Jabeena; Mir, Bilal Ahmad; Pilcher, Lynne A.; Riley, Darren L. (Elsevier, 2014-02)
    Cancer is one of the major causes of death and the number of new cases, as well as the number of individuals living with cancer, is expanding continuously. Worldwide the alarming rise in mortality rate due to cancer has ...
  • Targeted discovery of tetrapeptides and cyclic polyketide-peptide hybrids from a fungal antagonist of farming termites 
    Schalk, Felix; Um, Soohyun; Guo, Huijuan; Kreuzenbeck, Nina B.; Gorls, Helmar; De Beer, Z. Wilhelm; Beemelmanns, Christine (Wiley, 2020-10)
    Herein, we report the targeted isolation and characterization of four linear nonribosomally synthesized tetrapeptides (pseudoxylaramide A–D) and two cyclic nonribosomal peptide synthetase- polyketide synthase-derived ...