Browsing Genetics by Subject "Gametocytes"

Now showing items 1-6 of 6

Antimalarial benzimidazole derivatives incorporating phenolic Mannich base side chains inhibit microtubule and hemozoin formation : structure–activity relationship and in vivo oral efficacy studies

Dziwornu, Godwin Akpeko; Coertzen, Dina; Leshabane, Meta Kgaogelo; Korkor, Constance M.; Cloete, Cleavon K.; Njoroge, Mathew; Gibhard, Liezl; Lawrence, Nina; Reader, Janette; Van der Watt, Mariette Elizabeth; Wittlin, Sergio; Birkholtz, Lyn-Marie; Chibale, Kelly (American Chemical Society, 2021-04)

A novel series of antimalarial benzimidazole derivatives incorporating phenolic Mannich base side chains at the C2 position, which possess dual asexual blood and sexual stage activities, is presented. Structure–activity ...
Benzimidazole derivatives are potent against multiple life cycle stages of Plasmodium falciparum malaria parasites

Leshabane, Meta Kgaogelo; Dziwornu, Godwin Akpeko; Coertzen, Dina; Reader, Janette; Moyo, Phanankosi; Van der Watt, Mariette Elizabeth; Chisanga, Kelly; Nsanzubuhoro, Consolata; Ferger, Richard; Erlank, Erica; Venter, Nelius; Koekemoer, Lizette; Chibale, Kelly; Birkholtz, Lyn-Marie (American Chemical Society, 2021-03)

The continued emergence of resistance to front-line antimalarial treatments is of great concern. Therefore, new compounds that potentially have a novel target in various developmental stages of Plasmodium parasites are ...
Bioassay-guided isolation and identification of gametocytocidal compounds from Artemisia afra (Asteraceae)

Moyo, Phanankosi; Kunyane, Phaladi; Selepe, Mamoalosi A.; Eloff, Jacobus Nicolaas; Niemand, Jandeli; Louw, Abraham Izak; Maharaj, Vinesh J.; Birkholtz, Lyn-Marie (BioMed Central, 2019-03-08)

BACKGROUND : Optimal adoption of the malaria transmission-blocking strategy is currently limited by lack of safe and efficacious drugs. This has sparked the exploration of different sources of drugs in search of ...
Natural products : a potential source of malaria transmission blocking drugs?

Moyo, Phanankosi; Mugumbate, Grace; Eloff, Jacobus Nicolaas; Louw, Abraham Izak; Maharaj, Vinesh J.; Birkholtz, Lyn-Marie (MDPI Publishing, 2020-09-17)

The ability to block human-to-mosquito and mosquito-to-human transmission of Plasmodium parasites is fundamental to accomplish the ambitious goal of malaria elimination. The WHO currently recommends only primaquine as a ...
New transmission-selective antimalarial agents through hit-to-lead optimization of 2-([1,1 '-Biphenyl]-4-carboxamido)benzoic acid derivatives

Reader, Janette; Opperman, Daniel; Van der Watt, Mariette Elizabeth; Theron, Anjo; Leshabane, Meta Kgaogelo; Da Rocha, Michelle; Turner, Jonathan; Garrabrant, Kathleen; Pina, Ivett; Mills, Catherine; Woster, Patrick M.; Birkholtz, Lyn-Marie (Wiley, 2022-11)

Malaria elimination requires multipronged approaches, including the application of antimalarial drugs able to block humanto- mosquito transmission of malaria parasites. The transmissible gametocytes of Plasmodium ...
Optimal 10-aminoartemisinins with potent transmission-blocking capabilities for new artemisinin combination therapies–activities against blood stage P. falciparum including PfKI3 C580Y mutants and liver stage P. berghei parasites

Wong, Ho Ning; Padin-Irizarry, Vivian; Van der Watt, Mariette Elizabeth; Reader, Janette; Liebenberg, Wilna; Wiesner, Lubbe; Smith, Peter; Eribez, Korina; Winzeler, Elizabeth A.; Kyle, Dennis E.; Birkholtz, Lyn-Marie; Coertzen, Dina; Haynes, Richard K. (Frontiers Media, 2020-01-10)

We have demonstrated previously that amino-artemisinins including artemiside and artemisone in which an amino group replaces the oxygen-bearing substituents attached to C-10 of the current clinical artemisinin derivatives ...

Now showing items 1-6 of 6

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Browsing Genetics by Subject "Gametocytes"

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