Browsing Genetics by Title

Browsing Genetics by Title

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  • Machine learning uses chemo-transcriptomic profiles to stratify antimalarial compounds with similar mode of action 
    Van Heerden, Ashleigh; Van Wyk, Roelof Daniel Jacobus; Birkholtz, Lyn-Marie (Frontiers Media, 2021-06)
    The rapid development of antimalarial resistance motivates the continued search for novel compounds with a mode of action (MoA) different to current antimalarials. Phenotypic screening has delivered thousands of promising ...
  • Malaria vectors in the Democratic Republic of the Congo : the mechanisms that confer insecticide resistance in Anopheles gambiae and Anopheles funestus 
    Nardini, Luisa; Hunt, Richard H.; Dahan‑Moss, Yael L.; Christie, Nanette; Christian, Riann N.; Coetzee, Maureen; Koekemoer, Lizette L. (BioMed Central, 2017-11-07)
    BACKGROUND : The Democratic Republic of the Congo (DRC) is characterized as a holoendemic malaria area with the main vectors being Anopheles funestus and members of the Anopheles gambiae complex. Due to political ...
  • Management of hybridization in an endemic species : decision making in the face of imperfect information in the case of the black wildebeest-Connochaetes gnou 
    Grobler, J. Paul; Rushworth, Ian; Brink, James Simpson; Kotze, Antoinette; Bloomer, Paulette; Reilly, Brian Kevin; Vrahimis, Savvas (Springer, 2011-10)
    Hybridization between introduced and endemic ungulates, resulting from Anthropogenic actions, have been reported for several species. Several studies of such events contain the common themes of extralimital movements, ...
  • Mapping novel quantitative trait loci (QTL) associated with resistance to Pseudoidium neolycopersici in tomato 
    Treurnich, Annelize (University of Pretoria, 2021)
    The cultivated tomato (Solanum lycopersicum) is grown for both processing and fresh markets and is ranked as one of the most important vegetable crops globally. Its economic contribution to agriculture has permitted tomato ...
  • Mapping of the cytotoxic domains of protein VP5 of African horsesickness virus 
    Heinbockel, Britta Natassja (University of Pretoria, 2009-08-12)
    African horsesickness virus (AHSV) is a member of the Orbivirus genus of the Reoviridae family, being a double-layered capsid virus with a genome of ten double-stranded RNA segments. The outer capsid consists of two proteins, ...
  • MAT gene idiomorphs suggest a heterothallic sexual cycle in a predominantly asexual and important pine pathogen 
    Bihon, Wubetu; Wingfield, Michael J.; Slippers, Bernard; Duong, Tuan A.; Wingfield, Brenda D. (Elsevier, 2014-01)
    Diplodia pinea (=Sphaeropsis sapinea) is a well-known and economically important latent pathogen of Pinus spp. in many parts of the world. Despite intensive scrutiny, its sexual state has never been observed and the ...
  • Maternal effects on tree phenotypes : considering the microbiome 
    Vivas, Maria; Kemler, Martin; Slippers, Bernard (Elsevier, 2015-09)
    The biotic and abiotic environmental experience of plants can influence the offspring without any changes in DNA sequence. These effects can modulate the development of the progeny and its interaction with micro-organisms. ...
  • Maternal effects should be considered in the establishment of forestry plantations 
    Vivas, Maria; Wingfield, Michael J.; Slippers, Bernard (Elsevier, 2020-03)
    Breeding strategies for plants focus on the genetic influence on their phenotypes. However, the phenotype is not only the outcome of the genotype or the environmental conditions under which plants grow. It is important to ...
  • Maternal environment regulates morphological and physiological traits in Eucalyptus grandis 
    Vivas, Maria; Rolo, Victor; Wingfield, Michael J.; Slippers, Bernard (Elsevier, 2019-01)
    The phenotype of a plant can be shaped by the biotic and abiotic conditions to which their parents are subjected. This phenotypic plasticity known as maternal environmental effect occurs regardless of the changes in the ...
  • Mating genes in Calonectria and evidence for a heterothallic ancestral state 
    Li, JieQiong; Wingfield, Brenda D.; Wingfield, Michael J.; Barnes, Irene; Fourie, Arista; Crous, Pedro W.; Chen, S.F. (Naturalis Biodiversity Center and Centraalbureau voor Schimmelcultures, 2020-03-17)
    The genus Calonectria includes many important plant pathogens with a wide global distribution. In order to better understand the reproductive biology of these fungi, we characterised the structure of the mating type ...
  • Mating locus structure in Ceratocystis moniliformis and a gene duplication in Ceratocystis species 
    Godlonton, Tracy Alison (University of Pretoria, 2014)
    No abstract
  • Mating strategy and mating type distribution in six global populations of the Eucalyptus foliar pathogen Teratosphaeria destructans 
    Havenga, Minette; Wingfield, Brenda D.; Wingfield, Michael J.; Roets, Francois; Dreyer, Leanne Laurette; Tatham, Catherine; Duong, Tuan A.; Wilken, Pieter Markus; Chen, ShuaiFei; Aylward, Janneke (Elsevier, 2020-04)
    Teratosphaeria destructans is an aggressive fungal pathogen causing leaf and shoot blight on young Eucalyptus trees in plantations. The disease occurs across tropical and subtropical regions of South East Asia and has ...
  • The mating system of the Eucalyptus canker pathogen Chrysoporthe austroafricana and closely related species 
    Kanzi, Aquillah M.; Steenkamp, Emma Theodora; Van der Merwe, Nicolaas Albertus (Albie); Wingfield, Brenda D. (Elsevier, 2019-02)
    Fungi in the genus Chrysoporthe are economically important canker pathogens of commercially grown Eucalyptus species and native Myrtales. Before the current study, homothallism was widely accepted as the mating system of ...
  • Mating type and pheromone genes in the Gibberella fujikuroi species complex : an evolutionary perspective 
    Martin, Simon Henry (University of Pretoria, 2011-02-08)
    Reproductive isolation is an essential stage in speciation. In Ascomycetes, the ubiquitous distribution of many species suggests that sympatric speciation through assertive mating should be an important factor. The MAT ...
  • The mechanism of the amidases : mutating the glutamate adjacent to the catalytic triad inactivates the enzyme due to substrate mispositioning 
    Weber, Brandon W.; Kimani, Serah W.; Varsani, Arvind; Cowan, Don A.; Hunter, Roger; Venter, Gerhard A.; Gumbart, James C.; Sewell, B. Trevor (American Society for Biochemistry and Molecular Biology, 2013)
    All known nitrilase superfamily amidase and carbamoylase structures have an additional glutamate that is hydrogen bonded to the catalytic lysine in addition to the Glu, Lys, Cys “catalytic triad.” In the amidase from ...
  • Mechanisms that influence sex ratio variation in the invasive hymenopteran Sirex noctilio in South Africa 
    Queffelec, Josephine; Wooding, Amy L.; Greeff, Jaco M. (Jacobus Maree); Garnas, Jeffrey R.; Hurley, Brett Phillip; Wingfield, Brenda D.; Slippers, Bernard (Wiley Open Access, 2019-07)
    Sirex noctilio is an economically important invasive pest of commercial pine forestry in the Southern Hemisphere. Newly established invasive populations of this woodwasp are characterized by highly male‐biased sex ratios ...
  • Meeting report : 1st International Functional Metagenomics Workshop May 7–8, 2012, St. Jacobs, Ontario, Canada 
    Engel, Katja; Ashby, Deborah; Brady, Sean F.; Cowan, Don A.; Doemer, John; Edwards, Elizabeth A.; Fiebig, Klaus; Martens, Eric C.; McCormac, Dennis; Mead, David A.; Miyazaki, Kentaro; Moreno-Hagelsieb, Gabriel; O'gara, Fergal; Reid, Alexandra; Rose, David R.; Simonet, Pascal; Sjoling, Sara; Smalla, Kornelia; Streit, Wolfgang R.; Tedman-Jones, Jennifer; Valla, Svein; Wellington, Elizabeth; Wu, Cheng-Cang; Liles, Mark R.; Neufeld, Josh D.; Sessitsch, Angela; Charles, Trevor C. (2013)
    This report summarizes the events of the 1st International Functional Metagenomics Work-shop. The workshop was held on May 7 and 8, 2012, in St. Jacobs, Ontario, Canada and was focused on building an international functional ...
  • The Meloidogyne graminicola effector Mg16820 is secreted in the apoplast and cytoplasm to suppress plant host defense responses 
    Naalden, Diana; Haegeman, Annelies; De Almeida-Engler, Janice; Birhane Eshetu, Firehiwot; Bauters, Lander; Gheysen Godelieve (Wiley, 2018-11)
    On invasion of roots, plant‐parasitic nematodes secrete effectors to manipulate the cellular regulation of the host to promote parasitism. The root‐knot nematode Meloidogyne graminicola is one of the most damaging nematodes ...
  • Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers 
    Qian, Frank; Rookus, Matti A.; Leslie, Goska; Risch, Harvey A.; Greene, Mark H.; Aalfs, Cora M.; Adank, Muriel A.; Adlard, Julian; Agnarsson, Bjarni A.; Ahmed, Munaza; Aittomäki, Kristiina; Andrulis, Irene L.; Arnold, Norbert; Arun, Banu K.; Ausems, Margreet G.E.M.; Azzollini, Jacopo; Barrowdale, Daniel; Barwell, Julian; Benitez, Javier; Białkowska, Katarzyna; Bonadona, Valérie; Borde, Julika; Borg, Ake; Bradbury, Angela R.; Brunet, Joan; Buys, Saundra S.; Caldes, Trinidad; Caligo, Maria A.; Campbell, Ian; Carter, Jonathan; Chiquette, Jocelyne; Chung, Wendy K.; Claes, Kathleen B.M.; Collee, J. Margriet; Collonge-Rame, Marie-Agnes; Couch, Fergus J.; Daly, Mary B.; Delnatte, Capucine; Diez, Orland; Domchek, Susan M.; Dorfling, Cecilia Maria; Eason, Jacqueline; Easton, Douglas F.; Eeles, Ros; Engel, Christoph; Evans, D. Gareth; Faivre, Laurence; Feliubadalo, Lidia; Foretova, Lenka; Friedman, Eitan; Frost, Debra; Ganz, Patricia A.; Garber, Judy; Garcia-Barberan, Vanesa; Gehrig, Andrea; Glendon, Gord; Godwin, Andrew K.; Gomez Garcia, Encarna B.; Hamann, Ute; Hauke, Jan; Hopper, John L.; Hulick, Peter J.; Imyanitov, Evgeny N.; Isaacs, Claudine; Izatt, Louise; Jakubowska, Anna; Janavicius, Ramunas; John, Esther M.; Karlan, Beth Y.; Kets, Carolien M.; Laitman, Yael; Lazaro, Conxi; Leroux, Dominique; Lester, Jenny; Lesueur, Fabienne; Loud, Jennifer T.; Lubinski, Jan; Lukomska, Alicja; McGuffog, Lesley; Mebirouk, Noura; Meijers-Heijboer, Hanne E.J.; Meindl, Alfons; Miller, Austin; Montagna, Marco; Mooij, Thea M.; Mouret-Fourme, Emmanuelle; Nathanson, Katherine L.; Nehoray, Bita; Neuhausen, Susan L.; Nevanlinna, Heli; Nielsen, Finn C.; Offit, Kenneth; Olah, Edith; Ong, Kai-ren; Oosterwijk, Jan C.; Ottini, Laura; Parsons, Michael T.; Peterlongo, Paolo; Pfeiler, Georg; Pradhan, Nisha; Radice, Paolo; Ramus, Susan J.; Rantala, Johanna; Rennert, Gad; Robson, Mark; Rodriguez, Gustavo C.; Salani, Ritu; Scheuner, Maren T.; Schmutzler, Rita K.; Shah, Payal D.; Side, Lucy E.; Simard, Jacques; Singer, Christian F.; Steinemann, Doris; Stoppa-Lyonnet, Dominique; Tan, Yen Yen; Teixeira, Manuel R.; Terry, Mary Beth; Thomassen, Mads; Tischkowitz, Marc; Tognazzo, Silvia; Toland, Amanda Ewart; Tung, Nadine; Van Asperen, Christi J.; Van Engelen, Klaartje; Jansen van Rensburg, Elizabeth; Venat-Bouvet, Laurence; Vierstraete, Jeroen; Wagner, Gabriel; Walker, Lisa; Weitzel, Jeffrey N.; Yannoukakos, Drakoulis; KConFab Investigators; HEBON Investigators; GEMO Study Collaborators; EMBRACE Collaborators; Antoniou, Antonis C.; Goldgar, David E.; Olopade, Olufunmilayo I.; Chenevix-Trench, Georgia; Rebbeck, Timothy R.; Huo, Dezheng (Springer Nature, 2019-07)
    BACKGROUND : Height and body mass index (BMI) are associated with higher ovarian cancer risk in the general population, but whether such associations exist among BRCA1/2 mutation carriers is unknown. METHODS : We applied ...
  • Metabolomic and molecular signatures of Mascarene Aloes using a multidisciplinary approach 
    Govinden-Soulange, J.; Lobine, D.; Frederich, M.; Kodja, H.; Coetzee, Martin Petrus Albertus; Ranghoo-Sanmukhiya, V.M. (Elsevier, 2017-01)
    In this research a multidisciplinary approach was used to unveil the genetic, metabolic uniqueness and relationships of endemic Mascarene Aloes (Aloe macra, Aloe purpurea, Aloe tormentorii) with respect to Aloe vera. ...