Abstract:
The anthelmintic effect of acetone leaf extract and fractions of Anogeissus leiocarpus was investigated to determine the
relative efficacy of the components as anthelmintic against Haemonchus contortus (Rudolphi). The fractions were obtained by
solvent-solvent group separation of the leaf extract. The fractions were evaluated for ovicidal and larvicidal activity by egg hatch
inhibition assay and larval development viability assay. Best-fit LC50 values for egg hatch test were 0.360, 0.316, 0.093, 0.219
and 0.196 mg/ml for the crude acetone extract, hexane, chloroform, butanol, and 35% water in methanol fractions, respectively.
While the best-fit LC50 values for larval development and viability test were 0.509, 0.162, 0.186, 0.288 and 0.130 mg/ml for the
crude acetone extract, hexane, chloroform, butanol, and 35% water in methanol fractions, respectively. The 35% water in
methanol fractions was the more active on larvae, although differences in activity between fractions were not significant
(p>0.05). A. leiocarpus leaf extracts could find application in anthelmintic therapy in veterinary practice.
