Browsing Research Articles (Medical Microbiology) by Title

Browsing Research Articles (Medical Microbiology) by Title

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  • National sentinel site surveillance for antimicrobial resistance in Klebsiella pneumoniae isolates in South Africa, 2010 - 2012 
    Perovic, Olga; Singh-Moodley, A.; Duse, Adriano; Bamford, Colleen; Elliott, G.; Swe Swe-Han, K .; Kularatne, R.; Lowman, W.; Whitelaw, Andrew; Nana, Trusha; Wadula, Jeannette; Lekalakala, M. Ruth; Saif, A.; Fortuin De-Smidt, M.; Marais, E. (Health and Medical Publishing Group, 2014-08)
    BACKGROUND. The increasing rates of antimicrobial resistance observed in the nosocomial pathogen Klebsiella pneumoniae are of major public health concern worldwide. Objectives. To describe the antibiotic susceptibility ...
  • Nationwide and regional incidence of microbiologically confirmed pulmonary tuberculosis in South Africa, 2004-12 : a time series analysis 
    Nanoo, Ananta; Izu, Alane; Ismail, Nazir Ahmed; Ihekweazu, Chikwe; Abubakar, Ibrahim; Mametja, David; Madhi, Shabir A. (Elsevier, 2015-09)
    BACKGROUND : South Africa has the highest incidence of tuberculosis in the world, largely resulting from a high population prevalence of HIV infection. We investigated the incidence of microbiologically confirmed pulmonary ...
  • New horizons in the diagnosis of tuberculosis of the spine : the role of whole genome sequencing 
    Ngcelwane, M.V. (Mthunzi); Omar, Shaheed V.; Said, H.M. (Halima Mohammed); Bida, Nndweleni Meshack (Korean Society of Spine Surgery, 2023-06)
    STUDY DESIGN : Prospective study. PURPOSE : To evaluate the utility of whole genome sequencing (WGS) in drug resistance testing, lineage of the organisms, and organism-related factors responsible for bacilli settling in ...
  • Next-generation ion torrent sequencing of drug resistance mutations in Mycobacterium tuberculosis strains 
    Daum, Luke T.; Rodriguez, John D.; Worthy, Sue A.; Ismail, Nazir Ahmed; Omar, Shaheed Vally; Dreyer, Andries W.; Fourie, P.B. (Petrus Bernardus); Hoosen, Anwar Ahmed; Chambers, James P.; Fischer, Gerald W. (American Society for Microbiology, 2012-12)
    A novel protocol for full-length Mycobacterium tuberculosis gene analysis of first- and second-line drug resistance was developed using the Ion Torrent Personal Genome Machine (PGM). Five genes—rpoB (rifampin), katG ...
  • Next-generation sequencing for identifying pyrazinamide resistance in Mycobacterium tuberculosis 
    Daum, Luke T.; Fourie, P.B. (Petrus Bernardus); Bhattacharyya, Sanjib; Ismail, Nazir Ahmed; Gradus, Steve; Maningi, N.E. (Nontuthuko Excellent); Omar, Shaheed Vally; Fischer, Gerald W. (Oxford University Press, 2014-03-15)
    No abstract available.
  • Normal flora and bacterial vaginosis in pregnancy : an overview 
    Redelinghuys, Mathys J.; Ehlers, Marthie Magdaleen; Dreyer, Andries W.; Kock, Martha Magdalena (Taylor and Francis, 2016-05)
    The female genital tract is an intricate, yet balanced ecosystem that hosts a variety of different residential microflora. The physiological changes that occur during pregnancy may disrupt this balanced ecosystem and ...
  • Norovirus epidemiology in Africa : a review 
    Mans, Janet; Armah, George E.; Steele, Andrew Duncan; Taylor, Maureen B. (Public Library of Science, 2016-04-26)
    Norovirus (NoV) is recognised as a leading cause of gastroenteritis worldwide across all age groups. The prevalence and diversity of NoVs in many African countries is still unknown, although early sero-prevalence studies ...
  • A novel molecular strategy for surveillance of multidrug resistant tuberculosis in high burden settings 
    Said, Halima M.; Kushner, Nicole; Omar, Shaheed Vally; Dreyer, Andries W.; Koornhof, Hendrik; Erasmus, Linda; Gardee, Yasmin; Rukasha, Ivy; Shashkina, Elena; Beylis, Natalie; Kaplan, Gilla; Fallows, Dorothy; Ismail, Nazir Ahmed (Public Library of Science, 2016-01-11)
    BACKGROUND In South Africa and other high prevalence countries, transmission is a significant contributor to rising rates of multidrug resistant tuberculosis (MDR-TB). Thus, there is a need to develop an early detection ...
  • Occurrence of enterococci harbouring clinically important antibiotic resistance genes in the aquatic environment in Gauteng, South Africa 
    Hamiwe, Thabo; Kock, Marleen M.; Magwira, C.A. (Cliff); Antiabong, John Francis; Ehlers, Marthie Magdaleen (Elsevier, 2019-02)
    The development of antibiotic resistance and dissemination of its determinants is an emerging public health problem as it compromises treatment options of infections that were, until recently, treatable. Investigation of ...
  • Opsonic monoclonal antibodies enhance phagocytic killing activity and clearance of Mycobacterium tuberculosis from blood in a quantitative qPCR mouse model 
    Sei, Clara J.; Shey, Bong-Akee; Schuman, Richard F.; Rikhi, Nimisha; Muema, Kevin; Rodriguez, John D.; Daum, Luke T.; Fourie, P.B. (Petrus Bernardus); Fischer, Gerald W. (Elsevier, 2019-09)
    BACKGROUND : Patients with impaired immunity often have rapid progression of tuberculosis (TB) which can lead to highly lethal Mycobacterium tuberculosis (MTB) sepsis. Opsonic monoclonal antibodies (MABs) directed ...
  • Optimizing mycobacterial culture in smear-negative, human immunodeficiency virus-infected Tuberculosis cases 
    Ismail, Nazir Ahmed; Said, H.M. (Halima Mohammed); Pinini, Z.; Omar, Shaheed Vally; Beyers, N.; Naidoo, P. (Public Library of Science, 2015-11-06)
    INTRODUCTION Tuberculosis (TB) is a significant public health problem and the diagnosis in human immunodeficiency virus (HIV)—infected individuals is challenging. The use of mycobacterial culture remains an important ...
  • Orthobunyavirus antibodies among humans in selected parts of the Rift Valley and northeastern Kenya 
    Odhiambo, Collins; Venter, Marietjie; Swanepoel, Robert; Sang, Rosemary (Mary Ann Liebert, 2015-05)
    Ngari, Bunyamwera, Ilesha, and Germiston viruses are among the mosquito-borne human pathogens in the Orthobunyavirus genus, family Bunyaviridae, associated with febrile illness. Although the four orthobunyaviruses have ...
  • Outbreak of carbapenem-resistant Providencia rettgeri in a tertiary hospital 
    Tshisevhe, V.S.; Lekalakala, M.R.; Tshuma, N.; Janse van Rensburg, S.; Mbelle, Nontombi Marylucy (Health and Medical Publishing Group, 2017)
    The emergence of resistance to multiple antimicrobial agents in pathogenic bacteria is a significant public health threat, as there are limited effective antimicrobial agents for infections caused by multidrug-resistant ...
  • Outbreak of Ralstonia mannitolilytica bacteraemia in patients undergoing haemodialysis at a tertiary hospital in Pretoria, South Africa 
    Said, Mohamed; Van Hougenhouck-Tulleken, W.G. (Wesley); Naidoo, Rashmika; Mbelle, Nontombi Marylucy; Ismail, Farzana (BMC, 2020-07)
    BACKGROUND: Ralstonia species are Gram-negative bacilli of low virulence. These organisms are capable of causing healthcare associated infections through contaminated solutions. In this study, we aimed to determine the ...
  • Part IV. Human infections and antibiotic resistance 
    Crowther-Gibson, Penny; Govender, N.; Lewis, D.A.; Bamford, C.; Brink, A.; Von Gottberg, Anne; Klugman, Keith P.; Du Plessis, M.; Fali, A.; Harris, B.; Keddy, Karen H.; Botha, M. (Health and Medical Publishing Group, 2011-08)
    South Africa has a high burden of infectious diseases, including a large portion that are of bacterial origin. This section reviews the national burden of disease and levels of antibiotic resistance in common bacterial ...
  • Part V. Surveillance activities 
    Bamford, C.; Brink, A.; Govender, N.; Lewis, D.A.; Perovic, Olga; Botha, M.; Harris, B.; Keddy, Karen H.; Gelband, H.; Duse, A.G. (Health and Medical Publishing Group, 2011-08)
    The critical importance of robust antimicrobial resistance (AMR) surveillance in South Africa cannot be overemphasised. Without knowing what the resistance situation is, it is impossible to develop appropriate antibiotic ...
  • Part VII : Interventions 
    Visser, Adele; Moore, D.P.; Whitelaw, Andrew; Lowman, W.; Kantor, G.; Hoosen, Anwar Ahmed; Madhi, Shabir A.; Brink, A.; Van den Bergh, D.; Devenish, L.; Moodley, P.; Apalata, T.; Duse, A.G.; Gelband, H. (Health and Medical Publishing Group, 2011-08)
    Antimicrobial resistance (AMR) surveillance activities in South Africa have been described in Part V of this report. Surveillance – knowing the levels of resistance and the trends around the country and in different ...
  • Pathogenomics and evolutionary epidemiology of multi-drug resistant clinical Klebsiella pneumoniae isolated from Pretoria, South Africa 
    Mbelle, Nontombi Marylucy; Feldman, Charles; Osei Sekyere, John; Maningi, Nontuthuko Excellent; Modipane, Lesedi; Essack, Sabiha Yusuf (Nature Publishing Group, 2020)
    Antibiotic-resistant Klebsiella pneumoniae is increasingly being implicated in invasive infections worldwide with high mortalities. Forty-two multidrug resistant (MDR) K. pneumoniae isolates were collected over a 4-month ...
  • Patient with protracted abdominal pain 
    Nyapholi, Mohapi; Geldenhuys, Annelize; Visser, Adele (Federation of Infectious Diseases Societies of South Africa, 2013)
    Actinomycosis is very often misdiagnosed as typically, the associated laboratory and radiological findings are nonspecific. Therefore, clinicians should always have a high index of suspicion in cases in which there is ...
  • Pediatric disease burden and vaccination recommendations : understanding local differences 
    Gentile, Angela; Bhutta, Zulfiqar; Bravo, Lulu; Samy, Aly Gamal; Garcia, R. Dennis J.; Hoosen, Anwar Ahmed; Islam, Tazul; Karimi, Abdollah; Salem, Mona; Simasathien, Sriluck; Sohail, Amir; Watanaveeradej, Veerachai; Wiedenmayer, Karin; Schmitt, Heinz-J. (Elsevier, 2010)
    BACKGROUND: Diphtheria (D), tetanus (T), pertussis (P), hepatitis B (HepB), invasive Haemophilus influenzae type b (Hib) disease, and measles cause substantial global morbidity and mortality. METHODS: This unique review ...