Comparative genetics of sarcoid tumour-affected and non-affected mountain zebra (Equus zebra) populations

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dc.contributor.author Sasidharan, Sooryakanth P.
dc.contributor.author Ludwig, Anette
dc.contributor.author Harper, Cindy Kim
dc.contributor.author Moodley, Yoshan
dc.contributor.author Bertschinger, H.J. (Hendrik Jan)
dc.contributor.author Guthrie, Alan John
dc.contributor.editor Somers, Michael J.
dc.date.accessioned 2011-11-07T06:52:31Z
dc.date.available 2011-11-07T06:52:31Z
dc.date.issued 2011-04
dc.description.abstract In recent years, South African conservation officials have noted the appearance of sarcoid tumour-like growths in Cape mountain zebra (Equus zebra zebra) populations. In domestic horses (Equus ferus caballus), a genetic predisposition for this bovine papillomavirusinduced tumour is reported. This investigation compared population genetic parameters within tumour-affected populations in Bontebok National Park and Gariep Dam Nature Reserve against Cape mountain zebra populations having few or no tumours in Karoo National Park and Karoo Nature Reserve in South Africa and Hartmann’s mountain zebra populations from Namibia. Tumour-affected populations had the lowest levels of expected heterozygosity, gene diversity and polymorphism and highest values of internal relatedness and homozygosity by loci but not reaching levels of significance (P = 0.05). Wright’s FIS values indicated an overall deficit of heterozygotes in both affected and non-affected Cape mountain zebra populations. Considerable population substructuring, as indicated by FST values and Bayesian clustering, was revealed among all Cape mountain zebra populations. The results provide support for current conservation policies aimed at increasing levels of genetic diversity in isolated Cape mountain zebra populations. en
dc.description.sponsorship The Faculty of Veterinary Science of University of Pretoria, Equine Research Center and the Veterinary Wildlife Unit provided funding for the project. The Novartis Animal Health South Africa, in conjunction with the South African Veterinary Foundation is acknowledged for funding laboratory costs. en_US
dc.description.uri http://www.sawma.co.za/ en_US
dc.identifier.citation Sasidharan, SP, Ludwig, A, Harper, C, Moodley, Y, Bertschinger, HJ & Guthrie, AJ 2011, 'Comparative genetics of sarcoid tumour-affected and non-affected mountain zebra (Equus zebra) populations', South African Journal of Wildlife Research, vol. 41, no. 1, pp. 36–49. en
dc.identifier.issn 0379-4369
dc.identifier.other 7006535470
dc.identifier.other J-6375-2013
dc.identifier.other 0000-0001-7729-9918
dc.identifier.uri http://hdl.handle.net/2263/17511
dc.language.iso en en_US
dc.publisher Southern African Wildlife Management Association en_US
dc.rights Southern African Wildlife Management Association en
dc.subject Cape mountain zebra en
dc.subject Sarcoid tumour en
dc.subject.lcsh Mountain zebra -- South Africa -- Genetics en
dc.subject.lcsh Zebras -- South Africa -- Genetics en
dc.subject.lcsh Tumors in animals en
dc.subject.lcsh Papillomavirus diseases en
dc.subject.lcsh Inbreeding en
dc.title Comparative genetics of sarcoid tumour-affected and non-affected mountain zebra (Equus zebra) populations en
dc.type Article en


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