Browsing Research Articles (Biochemistry) by UP Author "Clark, Katherine"

Browsing Research Articles (Biochemistry) by UP Author "Clark, Katherine"

Sort by: Order: Results:

  • Exploring functional genomics for drug target and therapeutics discovery in Plasmodia 
    Birkholtz, Lyn-Marie; Van Brummelen, A.C. (Anna Catharina); Clark, Katherine; Niemand, Jandeli; Marechal, Eric; Llinas, M.; Louw, Abraham Izak (Elsevier, 2008-02)
    Functional genomics approaches are indispensable tools in the drug discovery arena and have recently attained increased attention in antibacterial drug discovery research. However, the application of functional genomics ...
  • Functional consequences of perturbing polyamine metabolism in the malaria parasite, Plasmodium falciparum 
    Clark, Katherine; Niemand, Jandeli; Reeksting, S.B. (Shaun Bernard); Smit, Salome; Van Brummelen, A.C. (Anna Catharina); Williams, Marni; Louw, Abraham Izak; Birkholtz, Lyn-Marie (Springer, 2010-02)
    Inhibition of polyamine biosynthesis and/or the perturbation of polyamine functionality have been exploited with success against parasitic diseases such as Trypanosoma infections. However, when the classical polyamine ...
  • Inducing controlled cell cycle arrest and re-entry during asexual proliferation of plasmodium falciparum malaria parasites 
    Van Biljon, Riette Andele; Niemand, Jandeli; Clark, Katherine; Verlinden, Bianca K.; Abrie, Clarissa; Von Gruning, Hilde; Smidt, Werner; Smit, Annel; Reader, Janette; Painter, Heather; Llinas, Manuel; Doerig, Christian; Birkholtz, Lyn-Marie (Nature Publishing Group, 2018-11-08)
    The life cycle of the malaria parasite Plasmodium falciparum is tightly regulated, oscillating between stages of intense proliferation and quiescence. Cyclic 48-hour asexual replication of Plasmodium is markedly different ...