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Browsing Research Articles (Chemistry) by Author "Panayides, Jenny-Lee"
Now showing items 1-6 of 6
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Stark, Roderick T.; Pye, Dominic R.; Chen, Wenyi; Newton, Oliver J.; Deadman, Benjamin J.; Miller, Philip W.; Panayides, Jenny-Lee; Riley, Darren L.; Hellgardt, Klaus; Hii, King Kuok (Mimi) (Royal Society of Chemistry, 2022-10)A synthetic route to an anti-cancer drug, lapatinib, was devised to support the development of a sustainable manufacturing process in South Africa. Quantitative metrics were employed to evaluate the sustainability of the ...
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Van der Westhuizen, Carl Johan; Van Greunen, D.G. (Divan); Cordier, Werner; Nell, Margo Judith; Steenkamp, Vanessa; Stander, Andre; Panayides, Jenny-Lee; Riley, Darren L. (ARKAT, 2020-04)β-Secretase (BACE1) is recognised as a target for the treatment of Alzheimer’s disease, and transition-state isosteres such as hydroxyethylamines have shown promise when incorporated into BACE1 inhibitors. A computational ...
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Neyt, Nicole Candice; Van der Westhuizen, C. Johan; Panayides, Jenny-Lee; Riley, Darren L. (Royal Society of Chemistry, 2022-08)Ozonolysis is an attractive, efficient, and green means of introducing oxygen containing functionalities using only oxygen and electricity. Unfortunately, safety issues associated with the accumulation of dissolved ozone ...
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Rants’o, Thankhoe A.; Van Greunen, D.G. (Divan); Van der Westhuizen, Carl Johan; Riley, Darren L.; Panayides, Jenny-Lee; Koekemoer, Lizette L.; Van Zyl, Robyn L. (Public Library of Science, 2022-11-09)Current studies on Anopheles anticholinesterase insecticides are focusing on identifying agents with high selectivity towards Anopheles over mammalian targets. Acetylcholinesterase (AChE) from electric eel is often used ...
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Wang, Simeng; Panayides, Jenny-Lee; Riley, Darren L.; Tighe, Christopher J.; Hellgardt, Klaus; Hii, King Kuok (Mimi); Miller, Philip W. (Royal Society of Chemistry, 2021-09)The functionalisation of imidazoles is a necessary step in the formation of many active pharmaceutical intermediates. Herein, we report a flow chemistry approach for the rapid and efficient formation of 2-lithio-1-(triph ...
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Van Wyk, Lorinda T.; Neyt, Nicole; Jugmohan, Jaimee; Panayides, Jenny-Lee; Riley, Darren L. (Royal Society of Chemistry, 2024-01)Globally, major depressive disorders are a leading cause of disconsolateness affecting more than 300 million individuals. Bupropion is a unique dopamine-norepinephrine reuptake inhibitor (DNRI) commonly utilized in the ...
Now showing items 1-6 of 6