The adeninate anion (Ade) is a useful nucleophile used in the synthesis of many prodrugs (including those for HIV AIDS treatment). It exists as a contact ion-pair (CIP) with Na+ and K+ (M+) but the site of coordination is ...
The alkylation of adenine using alkyl halides under basic conditions in
dimethyl sulfoxide (DMSO), a common reaction to achieve N9-alkylated adenine
derivatives, is often low yielding with unreacted adenine and ...
Rare anionic forms of nucleic acids play a significant biological role and lead to spontaneous mutations and replication and translational errors. There is a lack of information surrounding the stability and reactivity of ...
