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Browsing Research Articles (Oral Pathology and Oral Biology) by UP Author "Ambele, Melvin Anyasi"
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Ambele, Melvin Anyasi; Dhanraj, Priyanka; Giles, Rachel; Pepper, Michael Sean
(MDPI Publishing, 2020-06-16)
The formation of adipocytes during embryogenesis has been largely understudied.
However, preadipocytes appear to originate from multipotent mesenchymal stromal/stem cells which
migrate from the mesoderm to their anatomical ...
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Robinson, Liam; Abreu, Lucas Guimaraes; Fonseca, Felipe Paiva; Hunter, K.D. (Keith); Ambele, Melvin Anyasi; Van Heerden, Willem Francois Petrus
(Wiley, 2024-03)
BACKGROUND :
Ameloblastic carcinoma (AC) is the most common odontogenic malignancy, constituting approximately 30% of cases in this category. Literature is sparse on malignant odontogenic neoplasms, with a large proportion ...
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Ambele, Melvin Anyasi; Van Zyl, Andre; Pepper, Michael Sean; Van Heerden, Marlene B.; Van Heerden, Willem Francois Petrus
(Frontiers Media, 2020-04-30)
The lack of clinical biomarkers for head and neck cancer subtypes limits early diagnosis
and monitoring of disease progression. This study investigates genetic alterations
in clinically identical tumor, tumor-adjacent ...
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Tata, Emiliene B.; Ambele, Melvin Anyasi; Pepper, Michael Sean
(MDPI Publishing, 2020-08-26)
Clinical research in high-income countries is increasingly demonstrating the coste
ectiveness of clinical pharmacogenetic (PGx) testing in reducing the incidence of adverse drug
reactions and improving overall patient ...
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Damerell, Victoria; Ambele, Melvin Anyasi; Salisbury, Shanel; Neumann-Mufweba, Alexis; Durandt, Chrisna; Pepper, Michael Sean; Prince, Sharon
(Frontiers Media S.A., 2022-01-25)
Sarcomas are highly aggressive cancers of mesenchymal origin whose clinical
management is highly complex. This is partly due to a lack of understanding of the
molecular mechanisms underpinning the transformation of ...
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Ambele, Melvin Anyasi; Robinson, Liam; Van Heerden, M.B. (Marlene); Pepper, Michael Sean; Van Heerden, Willem Francois Petrus
(Elsevier, 2023-01)
Odontogenic keratocysts (OKCs) are common cysts of odontogenic origin that usually occur as a single nonsyndromic cyst in isolation (sporadic) or as syndromic multiple cysts as a manifestation of naevoid basal cell carcinoma ...
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Oloyo, Ahmed Kolade; Ambele, Melvin Anyasi; Pepper, Michael Sean
(Springer, 2017-11)
The effect of mesenchymal stromal/stem cells (MSCs) on tumour growth remains controversial. Experimental evidence supports both an inhibitory and a stimulatory effect. We have assessed factors responsible for the contrasting ...
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Peta, Kimberly; Durandt, Chrisna; Van Heerden, M.B. (Marlene); Joubert, Anna Margaretha; Pepper, Michael Sean; Ambele, Melvin Anyasi
(Wiley, 2023-10)
The prevalence of breast cancer (BC) continues to increase and is the leading cause
of cancer deaths in many countries. Numerous in vitro and in vivo studies have
demonstrated that 2‐methoxyestradiol (2‐ME) has ...
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Dessels, Carla; Ambele, Melvin Anyasi; Pepper, Michael Sean
(BMC, 2019-08)
BACKGROUND: For adipose-derived stromal cells (ASCs) to be safe for use in the clinical setting, they need to be prepared using good manufacturing practices (GMPs). Fetal bovine serum (FBS), used to expand ASCs in vitro ...
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Ambele, Melvin Anyasi; Pepper, Michael Sean; Van Heerden, Marlene B.; Van Heerden, Willem Francois Petrus
(Wiley, 2019-05)
BACKGROUND : Oral field cancerization describes a multifocal development process involving many cells at once in response to prolong exposure to carcinogens. This case demonstrated differential p16 expression in different ...
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Setlai, Botle Precious; Hull, Rodney; Reis, Rui Manuel; Agbor, Cyril; Ambele, Melvin Anyasi; Mulaudzi, Thanyani Victor; Dlamini, Zodwa
(MDPI, 2022-01-27)
MicroRNAs (miRNA) are small non-coding RNAs that are 20–23 nucleotides in length,
functioning as regulators of oncogenes or tumor suppressor genes. They are molecular modulators
that regulate gene expression by suppressing ...
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Ambele, Melvin Anyasi; Pepper, Michael Sean; Van Heerden, Marlene B.; Van Heerden, Willem Francois Petrus
(Wiley Open Access, 2019-06)
BACKGROUND : The occurrence of oral tongue squamous cell carcinoma (TSCC) in nonsmoking young adults, especially
females, has increased. Yet, there is no clear evidence to support the existence of any single determinant. ...
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Da Silva, C.; Durandt, Chrisna; Kallmeyer, Karlien; Ambele, Melvin Anyasi; Pepper, Michael Sean
(MDPI Publishing, 2020-06-09)
Obesity contributes significantly to the global health burden. A better understanding of
adipogenesis, the process of fat formation, may lead to the discovery of novel treatment strategies.
However, it is of concern that ...
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De Villiers, Danielle; Potgieter, Marnie; Ambele, Melvin Anyasi; Adam, Ladislaus; Durandt, Chrisna; Pepper, Michael Sean
(Springer, 2017-11)
Interest in reactive oxygen species and adipocyte differentiation/adipose tissue function is steadily increasing. This is due in part to a search for alternative avenues for combating obesity, which results from the excess ...
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Dhanraj, Priyanka; Van Heerden, Marlene B.; Pepper, Michael Sean; Ambele, Melvin Anyasi
(MDPI, 2021-07)
Despite obesity being a major health concern, information on the early clinical changes that
occur in plasma and tissues during obesity development and the influence of sexual dimorphism
is lacking. This study investigated ...
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Peta, Kimberly; Ambele, Melvin Anyasi; Pepper, Michael Sean
(Hindawi, 2021-03-30)
Tumours are characterized by a state of chronic inflammation and are regarded as wounds that never heal. Mesenchymal
stromal/stem cells (MSCs) are being considered as a possible treatment option. While MSCs can regulate ...
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Pitere, Reabetswe R.; Van Heerden, Marlene B.; Pepper, Michael Sean; Ambele, Melvin Anyasi
(MDPI, 2022-02)
Adipogenesis, through adipocyte hyperplasia and/or hypertrophy, leads to increased
adiposity, giving rise to obesity. A genome-wide transcriptome analysis of in vitro adipogenesis in
human adipose-derived stromal/stem ...