Total intravenous anaesthesia (TIVA) with propofol-fentanyl and propofol-midazolam combinations in spontaneously-breathing goats

Show simple item record Dzikiti, Tarisai Brighton Stegmann, George F. Dzikiti, Loveness Nyaradzo Hellebrekers, Ludo J. 2011-08-15T10:35:45Z 2011-08-15T10:35:45Z 2010-11
dc.description.abstract Objective To compare the efficacy and cardiopulmonary effects of propofol and fentanyl, with propofol and midazolam for total intravenous anaesthesia. Study design Prospective, randomized, crossover experimental study. Animals Six goats; three does and three wethers. Methods Goats received either fentanyl 0.02 mg kg−1 (treatment FP) or midazolam 0.3 mg kg−1 (treatment MP) intravenously. One minute later anaesthesia was induced with propofol, then maintained by constant rate infusion of propofol 12.0 mg kg−1 hour−1 and fentanyl 0.02 mg kg−1 hour−1 (treatment FP) or propofol 12.0 mg kg−1 hour−1 and midazolam 0.3 mg kg−1 hour−1 (treatment MP) for 90 minutes. Response to noxious stimulus was tested every 10 minutes and propofol dose adjusted to prevent purposeful movement. Cardiopulmonary parameters were measured continuously, and arterial blood-gas analysis performed intermittently. Recovery was timed and quality scored. Results are presented as median (IQR). Results Differences in the propofol induction dose [4.00 (3.96–4.01) and 3.97 (3.91–4.00) mg kg−1 for treatments FP and MP, respectively] were not significant. Quality of induction in both groups was smooth. The median propofol dose for maintenance was less (p = 0.004) with treatment FP (12.0 mg kg−1 hour−1) than MP (18.0 mg kg−1 hour−1). Cardiopulmonary function was well maintained with both treatments. Recovery times in minutes from the end of anaesthetic infusion for treatments FP and MP respectively were; to extubation 3.0 (3.0–3.0) and 4.5 (3.3–5.0); to sternal position, 4.5 (3.3–5.0) and 5.0 (5.0–6.5) and to standing 13.0 (10.3–15.0) and 15.0 (11.3–17.3). Quality of recovery was acceptable in both groups, but abnormal behavioural signs were observed after treatment FP. Conclusions and clinical relevance Total intravenous anaesthesia with propofol and fentanyl or propofol and midazolam, at the doses studied, in spontaneously-breathing, oxygen-supplemented goats is practicable. Recovery from the fentanyl-propofol combination is not always smooth. en
dc.description.sponsorship This study was jointly funded by the University of Pretoria; Fresenius Kabi, South Africa and the University of Pretoria / Utrecht University Memorandum of Understanding (UP/UU) MSc/PhD Research Fund. Gratitude is expressed to Ms Monicca Ngobeni of the University of Pretoria Biomedical Centre who worked tirelessly in offering technical support. en
dc.description.uri en
dc.identifier.citation Dzikti, BT, Stegmann, FG, Dzikiti, LN & Hellebrekers, LJ 2010, 'Total intravenous anaesthesia (TIVA) with propofol-fentanyl and propofol-midazolam combinations in spontaneously-breathing goats', Veterinary Anaesthesia and Analgesia, vol. 37, no. 6, pp. 519-525. en
dc.identifier.issn 1467-2987 (print)
dc.identifier.issn 1467-2995 (online)
dc.identifier.other 10.1111/j.1467-2995.2010.00568.x
dc.identifier.other 27967665100
dc.identifier.other N-8696-2014
dc.language.iso en en
dc.publisher Wiley Blackwell en
dc.rights Wiley-Blackwell. The definite version is available at en
dc.subject Anaesthesia en
dc.subject Constant rate infusion en
dc.subject Fentanyl en
dc.subject Goats en
dc.subject Midazolam en
dc.subject Propofol en
dc.subject.lcsh Goats -- Diseases en
dc.subject.lcsh Veterinary anesthesia en
dc.title Total intravenous anaesthesia (TIVA) with propofol-fentanyl and propofol-midazolam combinations in spontaneously-breathing goats en
dc.type Postprint Article en

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