dc.contributor.author |
Levine, Gwendolyn J.
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dc.contributor.author |
Levine, Jonathan M.
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dc.contributor.author |
Witsberger, Tige H.
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dc.contributor.author |
Kerwin, Sharon C.
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dc.contributor.author |
Russell, Karen E.
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dc.contributor.author |
Suchodolski, Jan
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dc.contributor.author |
Steiner, Jorg M.
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dc.contributor.author |
Fosgate, Geoffrey Theodore
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dc.date.accessioned |
2011-06-21T07:47:26Z |
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dc.date.available |
2011-06-21T07:47:26Z |
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dc.date.issued |
2010-07 |
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dc.description.abstract |
BACKGROUND: Release of myelin basic protein (MBP) into the cerebrospinal fluid (CSF)
is associated with active demyelination and correlates with outcome in various
neurological diseases.
HYPOTHESIS/OBJECTIVES: To describe associations between CSF MBP concentration,
initial neurological dysfunction, and long-term ambulatory outcome in dogs with acute
thoracolumbar intervertebral disk herniation (IVDH).
ANIMALS: 574 dogs with acute thoracolumbar IVDH and 16 clinically normal dogs.
METHODS: Prospective case series clinical study. Signalment, initial neurological
dysfunction as determined by a modified Frankel score (MFS), and ambulatory outcome
at > 3 month follow-up were recorded. Cisternal CSF MBP concentration was
determined using an enzyme-linked immunosorbent assay (ELISA). Associations were
estimated between CSF MBP concentration and various clinical parameters.
RESULTS: Dogs with thoracolumbar IVDH that did not ambulate at follow-up had a higher
CSF MBP concentration (median, 3.56 ng/ml; range, 0.59-51.2 ng/ml) compared to
control dogs (median, 2.22 ng/ml; range, 0-3.82 ng/ml) (P = 0.032). A CSF MBP
concentration of ≥ 3 ng/ml had a sensitivity of 78% and specificity of 76% to predict an
unsuccessful outcome based on receiver-operating characteristics curve analysis (area
under the curve = 0.688, P=0.079). Affected dogs with a CSF MBP concentration ≥ 3
ng/ml had 0.09 times the odds of ambulation at follow-up compared to affected dogs with
CSF MBP concentration <3 ng/ml when adjusted for initial MFS (95% CI 0.01-0.66, P =
0.018).
CONCLUSIONS AND CLINICAL IMPORTANCE: These results would suggest that CSF MBP concentration may be useful as an independent
prognostic indicator in dogs with thoracolumbar IVDH. |
en |
dc.description.sponsorship |
American Kennel Club ACORN grant #1180-A. |
en |
dc.identifier.citation |
Levine, GJ, Levine, JM, Witsberger, TH, Kerwin, SC, Russell, KE, Suchodolski, J, Steiner, J & Fosgate, GT 2010, 'Cerebrospinal fluid myelin basic protein as a prognostic biomarker in dogs with thoracolumbar intervertebral disk herniation', Journal of Veterinary Internal Medicine, vol. 24, no. 4, pp. 890-896. [http://www3.interscience.wiley.com/journal/118902531/home-6640&site=1] |
en |
dc.identifier.issn |
0891-6640 (print) |
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dc.identifier.issn |
1939-1676 (online) |
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dc.identifier.other |
10.1111/j.1939-1676.2010.0531.x |
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dc.identifier.other |
6603440077 |
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dc.identifier.uri |
http://hdl.handle.net/2263/16900 |
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dc.language.iso |
en |
en |
dc.publisher |
Wiley-Blackwell |
en |
dc.relation.requires |
Adobe Acrobat Reader |
en |
dc.rights |
Wiley-Blackwell. The definite version is available at www.blackwell-synergy.com. |
en |
dc.subject |
Spinal cord trauma |
en |
dc.subject |
Canid |
en |
dc.subject |
CSF analysis |
en |
dc.subject |
Intervertebral disk disease |
en |
dc.subject.lcsh |
Dogs |
en |
dc.subject.lcsh |
Cerebrospinal fluid proteins |
en |
dc.subject.lcsh |
Intervertebral disk -- Hernia |
en |
dc.title |
Cerebrospinal fluid myelin basic protein as a prognostic biomarker in dogs with thoracolumbar intervertebral disk herniation |
en |
dc.type |
Postprint Article |
en |