An insight into the sialome of blood feeding Nematocera

Show simple item record Ribeiro, Jose M.C. Mans, Ben J. (Barend Johannes) Arca, Bruno 2011-06-21T07:00:21Z 2011-06-21T07:00:21Z 2010-11
dc.description.abstract Within the Diptera and outside the suborder Brachycera, the blood feeding habit occurred at least twice, producing the present day sand flies, and the Culicomorpha, including the mosquitoes (Culicidae), black flies (Simulidae), biting midges (Ceratopogonidae) and frog feeding flies (Corethrellidae). Alternatives to this scenario are also discussed. Successful blood feeding requires adaptations to antagonize the vertebrate’s mechanisms of blood clotting, platelet aggregation, vasoconstriction, pain and itching, which are triggered by tissue destruction and immune reactions to insect products. Saliva of these insects provides a complex pharmacological armamentarium to block these vertebrate reactions. With the advent of transcriptomics, the sialomes (from the Greek word sialo=saliva) of at least two species of each of these families have been studied (except for the frog feeders), allowing an insight into the diverse pathways leading to today’s salivary composition within the Culicomorpha, having the sand flies as an outgroup. This review catalogs 1,288 salivary proteins in 10 generic classes comprising over 150 different protein families, most of which we have no functional knowledge. These proteins and many sequence comparisons are displayed in a hyperlinked spreadsheet that hopefully will stimulate and facilitate the task of functional characterization of these proteins, and their possible use as novel pharmacological agents and epidemiological markers of insect vector exposure. en
dc.identifier.citation Ribeiro, JMC, Mans, BJ & Arca, B 2010, 'An insight into the sialome of blood feeding Nematocera', Insect Biochemistry and Molecular Biology, vol. 40, no. 11, pp. 767-784. []] en
dc.identifier.issn 0965-1748 (print)
dc.identifier.issn 1879-0240 (online)
dc.identifier.other 10.1016/j.ibmb.2010.08.002
dc.language.iso en en
dc.publisher Elsevier en
dc.relation.requires Adobe Acrobat Reader en
dc.rights © 2010 Elsevier. en
dc.subject Salivary glands en
dc.subject Hematophagy en
dc.subject Mosquitoes en
dc.subject Sand flies en
dc.subject Black flies en
dc.subject Biting midges en
dc.subject Feeding habits en
dc.subject Vector en
dc.subject.lcsh Diptera en
dc.subject.lcsh Bloodsucking insects en
dc.title An insight into the sialome of blood feeding Nematocera en
dc.type Postprint Article en

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