Human papillomavirus (HPV)-associated oropharyngeal cancer (OPC) is on the increase and accounts for 18% to 63% of OPC.
It occurs mostly in young males with no other identifiable risk factors. The vast majority of HPV-associated OPC is attributable to
HPV16. The prognosis of patients with HPV-positive OPC is better than patients with HPV-negative OPC. Oral HPV infection is
linked to sexual transmission. The natural history, prevalence and possible risk factors in local communities should be studied to
implement appropriate prevention strategies.