Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century

Show simple item record Godfroid, Jacques Scholz, H.C. Barbier, T. Nicolas, C. Wattiau, P. Fretin, D. Whatmore, A.M. Cloeckaert, A. Blasco, J.M. Moriyon, I. Saegerman, Claude Muma, John B. Al Dahouk, Sascha Neubauer, H. Letesson, J.J. 2011-05-20T11:17:09Z 2011-05-20T11:17:09Z 2011-11
dc.description.abstract Following the recent discovery of new Brucella strains from different animal species and from the environment, ten Brucella species are nowadays included in the genus Brucella. Although the intracellular trafficking of Brucella is well described, the strategies developed by Brucella to survive and multiply in phagocytic and non-phagocytic cells, particularly to access nutriments during its intracellular journey, are still largely unknown. Metabolism and virulence of Brucella are now considered to be two sides of the same coin. Mechanisms presiding to the colonization of the pregnant uterus in different animal species are not known. Vaccination is the cornerstone of control programs in livestock and although the S19, RB51 (both in cattle) and Rev 1 (in sheep and goats) vaccines have been successfully used worldwide, they have drawbacks and thus the ideal brucellosis vaccine is still very much awaited. There is no vaccine available for pigs and wildlife. Animal brucellosis control strategies differ in the developed and the developing world. Most emphasis is put on eradication and on risk analysis to avoid the re-introduction of Brucella in the developed world. Information related to the prevalence of brucellosis is still scarce in the developing world and control programs are rarely implemented. Since there is no vaccine available for humans, prevention of human brucellosis relies on its control in the animal reservoir. Brucella is also considered to be an agent to be used in bio- and agroterrorism attacks. At the animal/ecosystem/human interface it is critical to reduce opportunities for Brucella to jump host species as already seen in livestock, wildlife and humans. This task is a challenge for the future in terms of veterinary public health, as for wildlife and ecosystem managers and will need a “One Health” approach to be successful. en
dc.identifier.citation Godfroid, J., et al., Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century. Preventive Veterinary Medicine, vol. 102, no. 2, pp. 118-131 (2011), doi:10.1016/j.prevetmed.2011.04.007 [] en
dc.identifier.issn 0167-5877 (print)
dc.identifier.issn 1873-1716 (online)
dc.identifier.other 10.1016/j.prevetmed.2011.04.007
dc.language.iso en en
dc.publisher Elsevier en
dc.relation.requires Adobe Acrobat Reader en
dc.rights © 2011 Elsevier B.V. All rights reserved. en
dc.subject Brucella en
dc.subject Taxonomy en
dc.subject Immunity en
dc.subject Virulence en
dc.subject Metabolism en
dc.subject Vaccines en
dc.subject Veterinary epidemiology en
dc.subject Zoonosis en
dc.subject Bioterrorism en
dc.subject One Health en
dc.subject.lcsh Brucellosis in animals en
dc.subject.lcsh Brucellosis en
dc.title Brucellosis at the animal/ecosystem/human interface at the beginning of the 21st century en
dc.type Postprint Article en

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